Title:
METHOD OF MONITORING BLOOD LOW MOLECULAR WEIGHT HEPARIN AND HEPARIN
Document Type and Number:
WIPO Patent Application WO1999010746
Kind Code:
A3
Abstract:
A method for determining the concentration of low molecular weight heparin or heparin in a blood plasma sample comprises the steps of: (a) adding a dilute thromboplastin (or tissue factor) solution to a blood plasma sample; and then (b) measuring the time to clot formation in said blood plasma sample. In one embodiment, the dilute thromboplastin (or tissue factor) solution is diluted prior to the adding step so that the time to clot formation in said blood plasma sample is at least 100 seconds when said blood plasma sample contains at least 1 mu g/ml of low molecular weight heparin.
Inventors:
WU HAI-FENG (US)
Application Number:
PCT/US1998/017434
Publication Date:
May 20, 1999
Filing Date:
August 25, 1998
Export Citation:
Assignee:
UNIV NORTH CAROLINA (US)
WU HAI FENG (US)
WU HAI FENG (US)
International Classes:
G01N33/86; (IPC1-7): G01N33/86
Foreign References:
| US5625036A | 1997-04-29 | |||
| EP0511075A1 | 1992-10-28 | |||
| US4415559A | 1983-11-15 | |||
| EP0219400A1 | 1987-04-22 |
Other References:
L NORRHEIM, U ABILDGAARD, M L LARSEN, A K LINDAHL: "Involvement of the Extrinsic Pathway in the Activities of Low Molecular Weight Heparins", THROMBOSIS RESEARCH. SUPPLEMENT (14), vol. 14, 1991, pages 19 - 27, XP002094528
O NORDFANG, H I KRISTENSEN, S VALENTIN, P OSTERGAARD, J WADT: "The Significance of TFPI in Clotting Assays - Comparison and Combination with Other Anticoagulants", THROMBOSIS AND HAEMOSTASIS, vol. 70, no. 3, 1 September 1993 (1993-09-01), pages 448 - 453, XP002094529
O NORDFANG, H I KRISTENSEN, S VALENTIN, P OSTERGAARD, J WADT: "The Significance of TFPI in Clotting Assays - Comparison and Combination with Other Anticoagulants", THROMBOSIS AND HAEMOSTASIS, vol. 70, no. 3, 1 September 1993 (1993-09-01), pages 448 - 453, XP002094529
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