Title:
METHOD FOR PREDICTING RESPONSE TO IMMUNE CHECKPOINT INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/059785
Kind Code:
A1
Abstract:
Provided is a method for predicting a response to an immune checkpoint inhibitor for a subject having cancer, the method comprising: a step (1) for determining one or more values or the presence or the absence of single nucleotide polymorphism (SNP), selected from the group consisting of: (i) abundance of microorganisms in feces or bowel content of the subject, (ii) genome pathway score in feces or bowel content of the subject, (iii) abundance of metabolic products in the blood, serum, or plasma of the subject, (iv) gene expression in the blood, serum or plasma of the subject, and (v) SNP of one or more genes selected from the group consisting of IL6R and NLRC5 of the subject; and a step (2) for predicting a response of the subject to an immune checkpoint inhibitor on the basis of the value obtained in the step (1).
Inventors:
SUNAKAWA YU (JP)
MATOBA RYO (JP)
MATOBA RYO (JP)
Application Number:
PCT/JP2021/034399
Publication Date:
March 24, 2022
Filing Date:
September 17, 2021
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
NON PROFIT ORGANIZATION JAPAN CLINICAL CANCER RES ORGANIZATION (JP)
NON PROFIT ORGANIZATION JAPAN CLINICAL CANCER RES ORGANIZATION (JP)
International Classes:
C12Q1/06; A61K39/395; A61P35/00; A61P37/02; C12N15/10; C12N15/12; C12Q1/68; G01N33/50
Other References:
SONG PENG: "Relationship between intestinal flora structure and metabolite analysis and immunotherapy efficacy in Chinese NSCLC patients", THORACIC CANCER, vol. 11, 23 April 2020 (2020-04-23), pages 1621 - 1632, XP055912534
MASATAKA ICHIKAWA: "Relationship between gut bacteria and immunity and malignant tumors", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, vol. 46, no. 12, 1 January 2019 (2019-01-01), JP , pages 1807 - 1813, XP009535226, ISSN: 0385-0684
SOUMAYA KOUIDHI, FARHAT BEN AYED, AMEL BENAMMAR ELGAAIED: "Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy", FRONTIERS IN IMMUNOLOGY, vol. 9, XP055757404, DOI: 10.3389/fimmu.2018.00353
BARTOUSKOVA M, SPISAROVÁ M, VITÁSKOVÁ D, ŠTUDENTOVÁ H,HUDCOVÁ M, ADAM T, MELICHAR B: "Association between neopterin and citrulline, a biomarker of gut function, during treatment with nivolumab", PTERIDINES, vol. 28, no. 1, 1 January 2017 (2017-01-01), pages 38, XP009535225, ISSN: 2195-4720
MUDD T. WILLIAM; LU CHUNWAN; KLEMENT JOHN D.; LIU KEBIN: "MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment", CELLULAR IMMUNOLOGY, vol. 360, 14 December 2020 (2020-12-14), US , XP086468303, ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2020.104260
CHATRATH AJAY, RATAN AAKROSH, DUTTA ANINDYA: "Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy", ISCIENCE, vol. 24, no. 3, 1 March 2021 (2021-03-01), US , pages 1 - 22, XP055912600, ISSN: 2589-0042, DOI: 10.1016/j.isci.2021.102248
OLBRYT MAGDALENA, RAJCZYKOWSKI MARCIN, WIDŁAK WIESŁAWA: "Biological Factors behind Melanoma Response to Immune Checkpoint Inhibitors", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 11, pages 1 - 20, XP055912603, DOI: 10.3390/ijms21114071
ABDEL-WAHAB NOHA; DIAB ADI; YU ROBERT K.; FUTREAL ANDREW; CRISWELL LINDSEY A.; TAYAR JEAN H.; DADU RAMONA; SHANNON VICKIE; SHETE S: "Genetic determinants of immune-related adverse events in patients with melanoma receiving immune checkpoint inhibitors", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 70, no. 7, 7 January 2021 (2021-01-07), Berlin/Heidelberg , pages 1939 - 1949, XP037479859, ISSN: 0340-7004, DOI: 10.1007/s00262-020-02797-0
OZCAN MINE, JANIKOVITS JONAS, VON KNEBEL DOEBERITZ MAGNUS, KLOOR MATTHIAS: "Complex pattern of immune evasion in MSI colorectal cancer", ONCOIMMUNOLOGY, vol. 7, no. 7, 3 July 2018 (2018-07-03), pages 1 - 10, XP055912652, DOI: 10.1080/2162402X.2018.1445453
DIMITRIOU FLORENTIA; HOGAN SABRINA; MENZIES ALEXANDER M.; DUMMER REINHARD; LONG GEORGINA V.: "Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy", EUROPEAN JOURNAL OF CANCER, vol. 157, 15 September 2021 (2021-09-15), Amsterdam NL , pages 214 - 224, XP086842431, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2021.08.031
MASATAKA ICHIKAWA: "Relationship between gut bacteria and immunity and malignant tumors", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, vol. 46, no. 12, 1 January 2019 (2019-01-01), JP , pages 1807 - 1813, XP009535226, ISSN: 0385-0684
SOUMAYA KOUIDHI, FARHAT BEN AYED, AMEL BENAMMAR ELGAAIED: "Targeting Tumor Metabolism: A New Challenge to Improve Immunotherapy", FRONTIERS IN IMMUNOLOGY, vol. 9, XP055757404, DOI: 10.3389/fimmu.2018.00353
BARTOUSKOVA M, SPISAROVÁ M, VITÁSKOVÁ D, ŠTUDENTOVÁ H,HUDCOVÁ M, ADAM T, MELICHAR B: "Association between neopterin and citrulline, a biomarker of gut function, during treatment with nivolumab", PTERIDINES, vol. 28, no. 1, 1 January 2017 (2017-01-01), pages 38, XP009535225, ISSN: 2195-4720
MUDD T. WILLIAM; LU CHUNWAN; KLEMENT JOHN D.; LIU KEBIN: "MS4A1 expression and function in T cells in the colorectal cancer tumor microenvironment", CELLULAR IMMUNOLOGY, vol. 360, 14 December 2020 (2020-12-14), US , XP086468303, ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2020.104260
CHATRATH AJAY, RATAN AAKROSH, DUTTA ANINDYA: "Germline variants predictive of tumor mutational burden and immune checkpoint inhibitor efficacy", ISCIENCE, vol. 24, no. 3, 1 March 2021 (2021-03-01), US , pages 1 - 22, XP055912600, ISSN: 2589-0042, DOI: 10.1016/j.isci.2021.102248
OLBRYT MAGDALENA, RAJCZYKOWSKI MARCIN, WIDŁAK WIESŁAWA: "Biological Factors behind Melanoma Response to Immune Checkpoint Inhibitors", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 11, pages 1 - 20, XP055912603, DOI: 10.3390/ijms21114071
ABDEL-WAHAB NOHA; DIAB ADI; YU ROBERT K.; FUTREAL ANDREW; CRISWELL LINDSEY A.; TAYAR JEAN H.; DADU RAMONA; SHANNON VICKIE; SHETE S: "Genetic determinants of immune-related adverse events in patients with melanoma receiving immune checkpoint inhibitors", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 70, no. 7, 7 January 2021 (2021-01-07), Berlin/Heidelberg , pages 1939 - 1949, XP037479859, ISSN: 0340-7004, DOI: 10.1007/s00262-020-02797-0
OZCAN MINE, JANIKOVITS JONAS, VON KNEBEL DOEBERITZ MAGNUS, KLOOR MATTHIAS: "Complex pattern of immune evasion in MSI colorectal cancer", ONCOIMMUNOLOGY, vol. 7, no. 7, 3 July 2018 (2018-07-03), pages 1 - 10, XP055912652, DOI: 10.1080/2162402X.2018.1445453
DIMITRIOU FLORENTIA; HOGAN SABRINA; MENZIES ALEXANDER M.; DUMMER REINHARD; LONG GEORGINA V.: "Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy", EUROPEAN JOURNAL OF CANCER, vol. 157, 15 September 2021 (2021-09-15), Amsterdam NL , pages 214 - 224, XP086842431, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2021.08.031
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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