Title:
METHOD FOR PREDICTING TERATOGENESIS
Document Type and Number:
WIPO Patent Application WO/2010/035885
Kind Code:
A1
Abstract:
Disclosed are: a method for predicting the teratogenesis of a chemical substance, which comprises the steps of (1) determining the activity of the chemical substance to inhibit the differentiation of a stem cell derived from a mammal (SD), the an activity of the chemical substance to inhibit the proliferation of a differentiated cell derived from a mammal (DG) and optionally the activity of the chemical substance to inhibit the proliferation of a stem cell derived from a mammal (SG), (2) comparing the inhibitory activity (SG) or the inhibitory activity (DG) with a reference value that is set in advance, and (3) comparing the inhibitory activity (SD) with the inhibitory activity (DG); and others.
Inventors:
HORIE NOBUYUKI (JP)
KAWAMURA SATOSHI (JP)
KAWAMURA SATOSHI (JP)
Application Number:
PCT/JP2009/067125
Publication Date:
April 01, 2010
Filing Date:
September 24, 2009
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
HORIE NOBUYUKI (JP)
KAWAMURA SATOSHI (JP)
HORIE NOBUYUKI (JP)
KAWAMURA SATOSHI (JP)
International Classes:
C12Q1/18
Other References:
SEILER, ANDREA ET AL: "Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test", REPRODUCTIVE TOXICOLOGY, vol. 18, no. 2, 2002, pages 231 - 240
NOBUYUKI HORIE ET AL.: "Haisei Kansaibo (ES saibo) o Riyo shita Anzensei Hyoka Kenkyu", SUMITOMO KAGAKU, vol. 2007-I, 2007, pages 49 - 55
SATOSHI KAWAMURA: "Kigyo ni Okeru Anzensei Hyoka no Tameno In vitro Shikenho no Genjo", FOLIA PHARMACOLOGICA JAPONICA, vol. 128, no. 5, 2006, pages 289 - 292
YAMAMOTO MEGUMI ET AL.: "Monitoring of gene expression in differentiation of embryoid bodies from cynomolgus monkey embryonic stem cells in the presence of bisphenol A.", THE JOURNAL OF TOXICOLOGICAL SCIENCES, vol. 32, no. 3, 2007, pages 301 - 310
STUMMANN, T. C. ET AL.: "Embryotoxicity hazard assessment of methylmercury and chromium using embryonic stem cells", TOXICOLOGY, vol. 242, no. 1-3, 2007, pages 130 - 143
NOBUYUKI HORIE ET AL.: "Haisei Kansaibo (ES saibo) o Riyo shita Anzensei Hyoka Kenkyu", SUMITOMO KAGAKU, vol. 2007-I, 2007, pages 49 - 55
SATOSHI KAWAMURA: "Kigyo ni Okeru Anzensei Hyoka no Tameno In vitro Shikenho no Genjo", FOLIA PHARMACOLOGICA JAPONICA, vol. 128, no. 5, 2006, pages 289 - 292
YAMAMOTO MEGUMI ET AL.: "Monitoring of gene expression in differentiation of embryoid bodies from cynomolgus monkey embryonic stem cells in the presence of bisphenol A.", THE JOURNAL OF TOXICOLOGICAL SCIENCES, vol. 32, no. 3, 2007, pages 301 - 310
STUMMANN, T. C. ET AL.: "Embryotoxicity hazard assessment of methylmercury and chromium using embryonic stem cells", TOXICOLOGY, vol. 242, no. 1-3, 2007, pages 130 - 143
Attorney, Agent or Firm:
NAKAYAMA, Tohru et al. (JP)
Toru Nakayama (JP)
Toru Nakayama (JP)
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