Title:
METHOD FOR PREPARAING NALTREXONE IMPLANT
Document Type and Number:
WIPO Patent Application WO/2020/037726
Kind Code:
A1
Abstract:
Disclosed is a method for preparing a naltrexone implant, comprising the following steps: (1) dissolving naltrexone and polylactic acid in an organic solvent to form microspheres, which are dried for subsequent use; (2) placing the naltrexone microspheres into a heated tablet mould for tableting to obtain a naltrexone implant; and (3) dissolving polylactic acid in an organic solvent to form a coating solution, which is placed in a coating trough, and soaking the naltrexone implant in the coating solution, followed by performing flotation drying. A certain amount of naltrexone crystals can also be added during tableting, which effectively avoids the problem of fracture of naltrexone microspheres during tableting. A special combination of the coating process with the flotation drying significantly increases the intactness and homogeneity of a coating. The naltrexone implant preparation method achieves a yield of more than 99%.
Inventors:
YIN SHUGUI (CN)
WANG SHIQIANG (CN)
JIA SHAOWEI (CN)
ZHANG TAO (CN)
LIU QINGZHE (CN)
WANG SHIQIANG (CN)
JIA SHAOWEI (CN)
ZHANG TAO (CN)
LIU QINGZHE (CN)
Application Number:
PCT/CN2018/104836
Publication Date:
February 27, 2020
Filing Date:
September 10, 2018
Export Citation:
Assignee:
SHENZHEN SCIENCARE MEDICAL IND CO LTD (CN)
International Classes:
A61K9/30; A61K9/32; A61K31/485; A61P25/32; A61P25/36
Foreign References:
| CN102512399A | 2012-06-27 | |||
| CN1973840A | 2007-06-06 | |||
| CN101700226A | 2010-05-05 | |||
| CN101612437A | 2009-12-30 | |||
| CN1415294A | 2003-05-07 | |||
| US20120164207A1 | 2012-06-28 |
Attorney, Agent or Firm:
JJS INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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