Title:
A METHOD FOR THE PREPARATION OF MONTELUKAST
Document Type and Number:
WIPO Patent Application WO2008083635
Kind Code:
B1
Abstract:
A method of preparation of Montelukast of formula (I) by reaction of the compound of formula (III) and a compound of formula (IX), characterized in that the reaction is carried out in the presence of a base, an inert solvent and a component increasing selectivity of the process, especially of a polyether of general formula (XIII), wherein R stands for hydrogen or an alkyl and the value of n varies from 1 to 40, polyethyleneglycol of general formula (XIV), wherein n=l to 40 or a crown-ether of formulae (XV), (XVI) or (XVII).
Inventors:
HALAMA ALES (CZ)
JIRMAN JOSEF (CZ)
JIRMAN JOSEF (CZ)
Application Number:
PCT/CZ2008/000002
Publication Date:
October 09, 2008
Filing Date:
January 08, 2008
Export Citation:
Assignee:
ZENTIVA AS (CZ)
HALAMA ALES (CZ)
JIRMAN JOSEF (CZ)
HALAMA ALES (CZ)
JIRMAN JOSEF (CZ)
International Classes:
C07D323/00; C07D215/18
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