Title:
METHOD FOR PREPARING 1-(TERT-BUTYL)-3-CHLORONAPHTHALENE
Document Type and Number:
WIPO Patent Application WO/2023/221165
Kind Code:
A1
Abstract:
The present application discloses a method for preparing 1-(tert-butyl)-3-chloronaphthalene, comprising: 1-naphthylamine and N-chlorosuccinimide reacting in a solvent to generate a first intermediate; the first intermediate and N-bromosuccinimide reacting in the solvent to generate a second intermediate; enabling a first reaction system containing the second intermediate, a Lewis acid, tert-butyl nitrite and the solvent to undergo a reaction, and then adding a hypophosphorous acid and cuprous oxide into the first reaction system to undergo a reaction to generate a third intermediate; and enabling a second reaction system containing a catalyst ligand, nickel acetylacetonate, lithium tert-butoxide, isopropylmagnesium chloride and the solvent to undergo a reaction in a protective atmosphere, and then adding the third intermediate into the second reaction system to undergo a reaction to generate 1-(tert-butyl)-3-chloronaphthalene. The preparation method of the present application is short in process route, simple in operation, mild in condition, environmentally friendly, low in cost, high in target product yield, few in by-products, and beneficial to industrial production.
Inventors:
CHENG CHUNWEN (CN)
GUO CHAO (CN)
LI SHUAI (CN)
DING ZONGCANG (CN)
ZHU YU (CN)
GUO CHAO (CN)
LI SHUAI (CN)
DING ZONGCANG (CN)
ZHU YU (CN)
Application Number:
PCT/CN2022/095676
Publication Date:
November 23, 2023
Filing Date:
May 27, 2022
Export Citation:
Assignee:
JIANGSU NANDA PHOTOELECTRIC MAT CO LTD (CN)
International Classes:
C07C17/263; C07C25/22
Domestic Patent References:
| WO2022017531A1 | 2022-01-27 | |||
| WO2021013978A1 | 2021-01-28 | |||
| WO2010102512A1 | 2010-09-16 |
Foreign References:
| CN107892702A | 2018-04-10 | |||
| CN107922836A | 2018-04-17 |
Other References:
LOHRE, C. ET AL.: "Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Tertiary Grignard Reagents Utilizing Donor-Functionalized N-Heterocyclic Carbenes (NHCs)", CHEMISTRY-A EUROPEAN JOURNAL, vol. 17, no. volume 22, 20 April 2011 (2011-04-20), pages 6052 - 6055, XP071833572, ISSN: 0947-6539, DOI: 10.1002/chem.201100909
REID JOLENE P., HU MINGYOU, ITO SUSUMU, HUANG BANRUO, HONG CYNTHIA M., XIANG HENGYE, SIGMAN MATTHEW S., TOSTE F. DEAN: "Strategies for remote enantiocontrol in chiral gold(iii) complexes applied to catalytic enantioselective γ,δ-Diels–Alder reactions", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 11, no. 25, 1 July 2020 (2020-07-01), United Kingdom , pages 6450 - 6456, XP093110143, ISSN: 2041-6520, DOI: 10.1039/D0SC00497A
REID JOLENE P., HU MINGYOU, ITO SUSUMU, HUANG BANRUO, HONG CYNTHIA M., XIANG HENGYE, SIGMAN MATTHEW S., TOSTE F. DEAN: "Strategies for remote enantiocontrol in chiral gold(iii) complexes applied to catalytic enantioselective γ,δ-Diels–Alder reactions", CHEMICAL SCIENCE, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 11, no. 25, 1 July 2020 (2020-07-01), United Kingdom , pages 6450 - 6456, XP093110143, ISSN: 2041-6520, DOI: 10.1039/D0SC00497A
Attorney, Agent or Firm:
SUZHOU XINZHIXING INTELLECTUAL PROPERTY AGENT FIRM (SPECIALGENERALPARTNERSHIP) (CN)
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