Title:
METHOD FOR PREPARING β-AMINO ACID DERIVATIVE RICH IN ENANTIOMERS
Document Type and Number:
WIPO Patent Application WO/2019/120000
Kind Code:
A1
Abstract:
Disclosed is a method for preparing a β-amino acid derivative rich in enantiomers, particularly a method for preparing sitagliptin. Blaise acid-base reaction, and an enzymatic reaction and a condensation reaction in any order are included. The substrate of the enzymatic reaction is a chiral β-aminoacrylic acid derivative.
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Inventors:
GAO ZHAOBO (CN)
CHEN JIANHUA (CN)
ZHANG XIANYI (CN)
HU LEI (CN)
HE ZHI (CN)
ZHENG HUI (CN)
MEI YIJIANG (CN)
CHEN JIANHUA (CN)
ZHANG XIANYI (CN)
HU LEI (CN)
HE ZHI (CN)
ZHENG HUI (CN)
MEI YIJIANG (CN)
Application Number:
PCT/CN2018/114448
Publication Date:
June 27, 2019
Filing Date:
November 08, 2018
Export Citation:
Assignee:
ZHEJIANG JIUZHOU PHARM CO LTD (CN)
International Classes:
C12P41/00; C07D487/04; C07K14/00
Foreign References:
| CN101802207A | 2010-08-11 | |||
| CN107604018A | 2018-01-19 |
Other References:
DATABASE PROTEIN 13 July 2007 (2007-07-13), ANONYMOUS: "NAPDH Dehydrogenase (Old Yellow Enzyme), Isoform 2 [Saccharomyces Cerevisiae YJM789)", XP055619823, retrieved from NCBI Database accession no. EDN62417
DATABASE PROTEIN 30 March 2017 (2017-03-30), ANONYMOUS: "NADPH Dehydrogenase NamA {Bacillus Subtilis)", XP055619824, retrieved from NCBI Database accession no. WP_080529515
DATABASE PROTEIN 2 October 2015 (2015-10-02), ANONYMOUS: "Alkene reductase [Enterobacter cloacae]", XP055619827, retrieved from NCBI Database accession no. WP_050871147
DATABASE PROTEIN 30 March 2017 (2017-03-30), ANONYMOUS: "NADPH Dehydrogenase NamA {Bacillus Subtilis)", XP055619824, retrieved from NCBI Database accession no. WP_080529515
DATABASE PROTEIN 2 October 2015 (2015-10-02), ANONYMOUS: "Alkene reductase [Enterobacter cloacae]", XP055619827, retrieved from NCBI Database accession no. WP_050871147
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