Title:
METHOD FOR PREPARING ANDROGRAPHOLIDE DERIVATIVE BY USING INDUSTRIAL CHROMATOGRAPHIC TECHNOLOGY
Document Type and Number:
WIPO Patent Application WO/2021/135783
Kind Code:
A1
Abstract:
Disclosed in the present invention is a method for preparing an andrographolide derivative by using an industrial chromatographic technology, comprising: first enriching andrographolide total sulfonate by means of a microporous adsorption resin, and then performing separation and purification by means of an industrial chromatographic column so as to obtain isoandrographolide-19-sodium sulfate, wherein the purity of isoandrographolide-19-sodium sulfate is more than 98%. The present invention can achieve real-time online monitoring during separation, is good in process reproducibility, simple to operate, short in preparation time, and small in the amount of a used organic solvent, and can be suitable for mass industrial production.
Inventors:
WANG ZHANGWEI (CN)
LIU DIFA (CN)
ZHANG YI (CN)
GU FUSHENG (CN)
ZHANG GONGJUN (CN)
LIANG JIA (CN)
ZHOU PENG (CN)
XIE BIAOPENG (CN)
YU SHUIPING (CN)
ZHANG JIUYUE (CN)
LIN FANG (CN)
LIU DIFA (CN)
ZHANG YI (CN)
GU FUSHENG (CN)
ZHANG GONGJUN (CN)
LIANG JIA (CN)
ZHOU PENG (CN)
XIE BIAOPENG (CN)
YU SHUIPING (CN)
ZHANG JIUYUE (CN)
LIN FANG (CN)
Application Number:
PCT/CN2020/132776
Publication Date:
July 08, 2021
Filing Date:
November 30, 2020
Export Citation:
Assignee:
JIANGXI QINGFENG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D307/92
Foreign References:
| CN103159720A | 2013-06-19 | |||
| CN101560198A | 2009-10-21 | |||
| CN1687049A | 2005-10-26 |
Other References:
XIAO XIAO-WU, FU HUI-ZHENG, LUO YUE-HUA, WEI XIAO-YI: "Potential anti-angiogenic sulfates of andrographolide", JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, GORDON AND BREACH, CHUR, CH, vol. 15, no. 8, 1 August 2013 (2013-08-01), CH, pages 809 - 818, XP055825365, ISSN: 1028-6020, DOI: 10.1080/10286020.2013.803473
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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