Title:
METHOD FOR PREPARING BILE ACID DERIVATIVE BY USING CONTINUOUS FLOW REACTION
Document Type and Number:
WIPO Patent Application WO/2018/194426
Kind Code:
A1
Abstract:
The present invention provides a method for preparing a bile acid derivative by using a continuous flow reaction. When a bile acid derivative is synthesized using a continuous flow reaction, according to the present invention, the reaction is very safe, the reaction time is greatly reduced and a high-quality bile acid derivative can be synthesized at high efficiency, in comparison with those of a conventional batch type reaction. Particularly, according to the present invention, since a hydrogenation reaction is carried out under a reaction condition substantially not comprising water, the conversion rate (UDCA:CDCA) of a UDCA hydrogenation reaction can be greatly improved.
Inventors:
HWANG TAE SEOP (KR)
KANG PHIL GOO (KR)
LEE JOON HWAN (KR)
EO JIN YONG (KR)
LEE SEUNG JAE (KR)
KANG PHIL GOO (KR)
LEE JOON HWAN (KR)
EO JIN YONG (KR)
LEE SEUNG JAE (KR)
Application Number:
PCT/KR2018/004639
Publication Date:
October 25, 2018
Filing Date:
April 20, 2018
Export Citation:
Assignee:
DAEWOONG BIO INC (KR)
International Classes:
C07J9/00
Domestic Patent References:
| WO2017019524A1 | 2017-02-02 | |||
| WO2013192097A1 | 2013-12-27 | |||
| WO2006122977A2 | 2006-11-23 |
Foreign References:
| JPH0559093A | 1993-03-09 | |||
| CN106046095A | 2016-10-26 | |||
| CN102070693A | 2011-05-25 | |||
| CN105315320A | 2016-02-10 |
Other References:
TIAN, H. ET AL.: "Catalytic Transfer Hydrogenation of 7-ketolithocholic Acid to Ursodeoxycholic Acid with Raney Nickel", JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, vol. 19, no. 2, 25 March 2013 (2013-03-25), pages 606 - 613, XP055559891, Retrieved from the Internet
See also references of EP 3613754A4
See also references of EP 3613754A4
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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