Title:
METHOD FOR PREPARING C-MET TYROSINE KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/101885
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a c-Met tyrosine kinase inhibitor, and specifically, relates to a method for preparing a mesylate crystalline form III of a compound represented by formula (I), namely 9-((8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl)-thioxo)-4-methyl-2H-[1,4]oxazino[3,2-c]quinoline-3(4H)-keto. This method has a short process path and mild reaction conditions, is controllable and very suitable for industrial production, and has a low pollution level and a high product yield. The compound prepared by the method has high purity.
Inventors:
YANG BAOHAI (CN)
ZHU QIANG (CN)
PAN BIGAO (CN)
ZHU QIANG (CN)
PAN BIGAO (CN)
Application Number:
PCT/CN2016/111486
Publication Date:
June 22, 2017
Filing Date:
December 22, 2016
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
International Classes:
C07D519/00
Domestic Patent References:
| WO2014180182A1 | 2014-11-13 | |||
| WO2013038362A1 | 2013-03-21 | |||
| WO2016015653A1 | 2016-02-04 |
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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