Title:
METHOD FOR PREPARING CERAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/063466
Kind Code:
A1
Abstract:
Disclosed is a method for preparing a ceramide compound. Specifically, provided is a method for synthesizing ceramide by reaction of phytosphingosine and a methyl ester-based compound represented by chemical formula 2, as starting materials, in the presence of a cyclic amine base-based catalyst. The use of the cyclic amine base-based catalyst enables the synthesis of ceramide at high yield even under relatively mild conditions.
Inventors:
CHO SE HYEON (KR)
EOM HYUN JI (KR)
KIM SEON KI (KR)
KIM NA RAE (KR)
CHA KYUNG ON (KR)
EOM HYUN JI (KR)
KIM SEON KI (KR)
KIM NA RAE (KR)
CHA KYUNG ON (KR)
Application Number:
PCT/KR2021/015416
Publication Date:
April 20, 2023
Filing Date:
October 29, 2021
Export Citation:
Assignee:
BJBIOCHEM CO LTD (KR)
International Classes:
C07C231/12; C07C235/08; C07C235/26; C07C235/28
Domestic Patent References:
| WO2019224356A1 | 2019-11-28 | |||
| WO2009150022A2 | 2009-12-17 |
Foreign References:
| KR20140060505A | 2014-05-20 |
Other References:
SABOT, C. KUMAR, K.A. MEUNIER, S. MIOSKOWSKI, C.: "A convenient aminolysis of esters catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) under solvent-free conditions", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM , NL, vol. 48, no. 22, 3 May 2007 (2007-05-03), Amsterdam , NL , pages 3863 - 3866, XP022058997, ISSN: 0040-4039, DOI: 10.1016/j.tetlet.2007.03.146
WEIBERTH FRANZ J., YU YONG, SUBOTKOWSKI WITOLD, PEMBERTON CLIVE: "Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 12, 21 December 2012 (2012-12-21), US , pages 1967 - 1969, XP093058738, ISSN: 1083-6160, DOI: 10.1021/op300210j
WEIBERTH FRANZ J., YU YONG, SUBOTKOWSKI WITOLD, PEMBERTON CLIVE: "Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 16, no. 12, 21 December 2012 (2012-12-21), US , pages 1967 - 1969, XP093058738, ISSN: 1083-6160, DOI: 10.1021/op300210j
Attorney, Agent or Firm:
ECM IP & LAW FIRM (KR)
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