Title:
METHOD FOR PREPARING EFFICIENT ANTI-TUMOR ACTIVE POLYPEPTIDE TUBULYSIN M
Document Type and Number:
WIPO Patent Application WO/2021/232791
Kind Code:
A1
Abstract:
Provided is a method for preparing an efficient anti-tumor active polypeptide Tubulysin M. The method comprises the steps of: S1, providing compound 2; and S2, preparing the active polypeptide Tubulysin M by taking the compound 2 as a key raw material. In the preparation method, an innovative route is used, the total synthesis process of the active polypeptide Tubulysin M is optimized, the total yield is relatively high, and the stereoselectivity is good.
Inventors:
WU ZHENGZHI (CN)
LONG BOHUA (CN)
LONG BOHUA (CN)
Application Number:
PCT/CN2020/139772
Publication Date:
November 25, 2021
Filing Date:
December 26, 2020
Export Citation:
Assignee:
SHENZHEN INST GERIATRICS (CN)
WU ZHENGZHI (CN)
WU ZHENGZHI (CN)
International Classes:
C07K5/078; C07K1/02; C07K1/16
Domestic Patent References:
| WO2017031209A1 | 2017-02-23 |
Foreign References:
| CN111690036A | 2020-09-22 | |||
| CN111647040A | 2020-09-11 | |||
| CN109912683A | 2019-06-21 | |||
| CN102695714A | 2012-09-26 | |||
| CN109678929A | 2019-04-26 |
Other References:
LONG, B. ET AL.: "“Total synthesis of tubulysin U and N14-desacetoxy tubulysin H”", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 18, 3 July 2020 (2020-07-03)
PETER WIPF, TAKESHI TAKADA, MICHAEL J. RISHEL: "Synthesis of the Tubuvaline-Tubuphenylalanine (Tuv-Tup) Fragment of Tubulysin", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 6, no. 22, 1 October 2004 (2004-10-01), US , pages 4057 - 4060, XP055532591, ISSN: 1523-7060, DOI: 10.1021/ol048252i
PETER WIPF, TAKESHI TAKADA, MICHAEL J. RISHEL: "Synthesis of the Tubuvaline-Tubuphenylalanine (Tuv-Tup) Fragment of Tubulysin", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 6, no. 22, 1 October 2004 (2004-10-01), US , pages 4057 - 4060, XP055532591, ISSN: 1523-7060, DOI: 10.1021/ol048252i
Attorney, Agent or Firm:
SHINY INTELLECTUAL PROPERTY FIRM (CN)
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