Title:
METHOD FOR PREPARING ENGINEERED TISSUE
Document Type and Number:
WIPO Patent Application WO2004007699
Kind Code:
A3
Abstract:
A method for preparing a human or animal tissue by applying a compressive force to a stack of sheets of living tissue thereby inducing adjacent layers to fuse or adhere to each other. The force is applied in direction normal to the surface of the tissue. A multi-layer tissue produced by the method decribed above can also possess at least two different types of sheets and/or consist essentially of between two and twelve sheets of living tissue. The method can also be used to prepare a planar tissue that can further be incorporated in a multi-layer tissue construct. The methods and tissues described herein are useful for the preparation of engineered tissues.
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Inventors:
GERMAIN LUCIE (CA)
AUGER FRANCOIS (CA)
BERGERON FRANCOIS (CA)
ROBERGE CHARLES (CA)
AUGER FRANCOIS (CA)
BERGERON FRANCOIS (CA)
ROBERGE CHARLES (CA)
Application Number:
PCT/CA2003/001079
Publication Date:
April 08, 2004
Filing Date:
July 16, 2003
Export Citation:
Assignee:
ALTERTEK BIO INC (CA)
GERMAIN LUCIE (CA)
AUGER FRANCOIS (CA)
BERGERON FRANCOIS (CA)
ROBERGE CHARLES (CA)
GERMAIN LUCIE (CA)
AUGER FRANCOIS (CA)
BERGERON FRANCOIS (CA)
ROBERGE CHARLES (CA)
International Classes:
A61L27/00; A61F2/02; C12N5/00; (IPC1-7): C12N5/06
Domestic Patent References:
| WO1996031226A1 | 1996-10-10 | |||
| WO1997037613A1 | 1997-10-16 | |||
| WO1999005262A2 | 1999-02-04 | |||
| WO2000069355A1 | 2000-11-23 | |||
| WO2003007795A2 | 2003-01-30 | |||
| WO2003045458A1 | 2003-06-05 |
Other References:
LOPEZ VALLE C A ET AL: "Peripheral anchorage of dermal equivalents", BRITISH JOURNAL OF DERMATOLOGY, vol. 127, no. 4, 1992, pages 365 - 371, XP009021181, ISSN: 0007-0963
YE Q ET AL: "Tissue engineering in cardiovascular surgery: new approach to develop completely human autologous tissue", EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, SPRINGER VERLAG, BERLIN, DE, vol. 17, April 2000 (2000-04-01), pages 449 - 454, XP002959353, ISSN: 1010-7940
L'HEUREUX N ET AL: "A COMPLETELY BIOLOGICAL TISSUE-ENGINEERED HUMAN BLOOD VESSEL", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 12, 1998, pages 47 - 57, XP002942845, ISSN: 0892-6638
KIM B-S ET AL: "CYCLIC MECHANICAL STRAIN REGULATES THE DEVELOPMENT OF ENGINEERED SMOOTH MUSCLE TISSUE", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 10, October 1999 (1999-10-01), pages 979 - 983, XP001145976, ISSN: 1087-0156
KEIICHI KANDA ET AL: "MECHANICAL STRESS INDUCED CELLULAR ORIENTATION AND PHENOTYPIC MODULATION OF 3-D CULTURED SMOOTH MUSCLE CELLS", ASAIO JOURNAL, J.B.LIPPINCOTT CO.,HAGERSTOWN,MD, US, vol. 39, no. 3, 1 July 1993 (1993-07-01), pages M686 - M690, XP000412635, ISSN: 1058-2916
YE Q ET AL: "Tissue engineering in cardiovascular surgery: new approach to develop completely human autologous tissue", EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, SPRINGER VERLAG, BERLIN, DE, vol. 17, April 2000 (2000-04-01), pages 449 - 454, XP002959353, ISSN: 1010-7940
L'HEUREUX N ET AL: "A COMPLETELY BIOLOGICAL TISSUE-ENGINEERED HUMAN BLOOD VESSEL", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, BETHESDA, MD, US, vol. 12, 1998, pages 47 - 57, XP002942845, ISSN: 0892-6638
KIM B-S ET AL: "CYCLIC MECHANICAL STRAIN REGULATES THE DEVELOPMENT OF ENGINEERED SMOOTH MUSCLE TISSUE", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 10, October 1999 (1999-10-01), pages 979 - 983, XP001145976, ISSN: 1087-0156
KEIICHI KANDA ET AL: "MECHANICAL STRESS INDUCED CELLULAR ORIENTATION AND PHENOTYPIC MODULATION OF 3-D CULTURED SMOOTH MUSCLE CELLS", ASAIO JOURNAL, J.B.LIPPINCOTT CO.,HAGERSTOWN,MD, US, vol. 39, no. 3, 1 July 1993 (1993-07-01), pages M686 - M690, XP000412635, ISSN: 1058-2916
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