Title:
METHOD FOR PREPARING FORODESINE
Document Type and Number:
WIPO Patent Application WO/2022/022376
Kind Code:
A1
Abstract:
The present invention relates to the technical field of chemical drug synthesis, and specifically relates to a method for preparing a compound as shown in formula I, comprising: treating the compound as shown in formula VII with an acid to generate the compound as shown in formula I. The method has few synthetic process steps, raw materials which is stable and is easy to prepare, a reaction process which is easy to control, and a high overall yield and purity, and is suitable for industrial preparation. [Formula I] [Formula VII]
Inventors:
QIN YONG (CN)
ZHONG WU (CN)
XUE FEI (CN)
ZHANG MINJIE (CN)
FAN SHIYONG (CN)
ZHENG ZHIBING (CN)
LI SONG (CN)
ZHONG WU (CN)
XUE FEI (CN)
ZHANG MINJIE (CN)
FAN SHIYONG (CN)
ZHENG ZHIBING (CN)
LI SONG (CN)
Application Number:
PCT/CN2021/107836
Publication Date:
February 03, 2022
Filing Date:
July 22, 2021
Export Citation:
Assignee:
UNIV SICHUAN (CN)
ACAD OF MILITARY MEDICAL SCIENCES (CN)
ACAD OF MILITARY MEDICAL SCIENCES (CN)
International Classes:
C07D487/04
Domestic Patent References:
| WO2014078778A2 | 2014-05-22 |
Foreign References:
| CN111704619A | 2020-09-25 | |||
| CN107108639A | 2017-08-29 | |||
| CN202010752502A | 2020-07-30 | |||
| US20180258091A1 | 2018-09-13 |
Other References:
KAMATH, V.P. ; XUE, J. ; JUAREZ-BRAMBILA, J.J. ; MORRIS, C.B. ; GANORKAR, R. ; MORRIS, P.E.: "Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 10, 15 May 2009 (2009-05-15), AMSTERDAM, NL , pages 2624 - 2626, XP026085929, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.04.017
KAMATH, V.P. ; XUE, J. ; JUAREZ-BRAMBILA, J.J. ; MORRIS, C.B. ; GANORKAR, R. ; MORRIS, P.E.: "Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 10, 15 May 2009 (2009-05-15), AMSTERDAM, NL , pages 2624 - 2626, XP026085929, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.04.017
NATURE, vol. 508, 2014, pages 402 - 405
TETRAHEDRON, vol. 65, 2009, pages 93 - 100
JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 17, 2001, pages 5723 - 5730
KAMATH, V.P. ; XUE, J. ; JUAREZ-BRAMBILA, J.J. ; MORRIS, C.B. ; GANORKAR, R. ; MORRIS, P.E.: "Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor-Part I", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 10, 15 May 2009 (2009-05-15), AMSTERDAM, NL , pages 2624 - 2626, XP026085929, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.04.017
NATURE, vol. 508, 2014, pages 402 - 405
TETRAHEDRON, vol. 65, 2009, pages 93 - 100
JOURNAL OF ORGANIC CHEMISTRY, vol. 66, no. 17, 2001, pages 5723 - 5730
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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