Title:
METHOD FOR PREPARING GLP-1 RECEPTOR AGONIST
Document Type and Number:
WIPO Patent Application WO/2021/238962
Kind Code:
A1
Abstract:
A method for preparing a GLP-1 receptor agonist, and more particularly, relates to an industrial preparation method for a GLP-1 receptor agonist (S)-2-(3S,8S)-3-(4-(3,4-dichlorobenzyloxy)phenyl-7-((S)-1-phenylpropyl)-2,3,6,7,8,9-hexahydro-[1,4]-dioxacyclohexene[2,3-g]isoquinoline-8-carboxamido)-3-(4-(2,3-dimethylpyridin-4-yl)phenyl)propanoic acid dihydrochloride (compound I). Compound 1 is used as a raw material, and is subjected to nucleophilic addition, hydrolysis, reductive amination, cyclization, amide condensation, hydrolysis and a salt formation reaction so as to prepare compound I. The total yield of Compound I prepared by this method reaches 35% or more, and the purity reaches 98% or more.
Inventors:
HU FAN (CN)
ZHOU YUBAO (CN)
FANG LI (CN)
HU HAIWEN (CN)
XU ZHONGJUN (CN)
ZHOU YUBAO (CN)
FANG LI (CN)
HU HAIWEN (CN)
XU ZHONGJUN (CN)
Application Number:
PCT/CN2021/095963
Publication Date:
December 02, 2021
Filing Date:
May 26, 2021
Export Citation:
Assignee:
HANGZHOU ZHONGMEIHUADONG PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D217/02; A61K31/472; A61K31/4741; A61P3/04; A61P3/10; C07D217/18; C07D217/20
Domestic Patent References:
| WO2019217165A1 | 2019-11-14 | |||
| WO2007093013A1 | 2007-08-23 |
Foreign References:
| CN102378574A | 2012-03-14 | |||
| CN1764647A | 2006-04-26 | |||
| CN102378574A | 2012-03-14 |
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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