Title:
METHOD FOR PREPARING GLUCOPYRANOSYL DERIVATIVES AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/007838
Kind Code:
A1
Abstract:
A method for preparing glucopyranosyl derivatives as sodium dependent glucose cotransporter (SGLT) inhibitors, an intermediate thereof, and a method for preparing the intermediate. The method has simple operation, simple post-treatment, easy purification, high total yield, high optical purity of the product, safe and controllable process, and is suitable for industrial production.
Inventors:
GU ZHENG (CN)
QU TONG (CN)
WU WUYONG (CN)
HUANG WEIMING (CN)
CHEN DAOQIAN (CN)
ZHANG ZONGYUAN (CN)
QIN HAOXIONG (CN)
LI ZHENG (CN)
YUAN WEIHUI (CN)
NIU SHIJIE (CN)
PENG FEI (CN)
WU TIANYUN (CN)
QU TONG (CN)
WU WUYONG (CN)
HUANG WEIMING (CN)
CHEN DAOQIAN (CN)
ZHANG ZONGYUAN (CN)
QIN HAOXIONG (CN)
LI ZHENG (CN)
YUAN WEIHUI (CN)
NIU SHIJIE (CN)
PENG FEI (CN)
WU TIANYUN (CN)
Application Number:
PCT/CN2021/104973
Publication Date:
January 13, 2022
Filing Date:
July 07, 2021
Export Citation:
Assignee:
DONGGUAN HEC NEW DRUG R & D CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07H9/04; C07H1/00
Domestic Patent References:
| WO2020143653A1 | 2020-07-16 | |||
| WO2014159151A1 | 2014-10-02 |
Foreign References:
| CN106083943A | 2016-11-09 |
Other References:
BOWLES PAUL ET AL.: "Commercial route research and development for SGLT2 inhibitor candidate ertugliflozin", ORG. PROCESS RES. DEV., vol. 18, 20 December 2013 (2013-12-20), pages 66 - 81, XP055283061, DOI: 10.1021/op4002802
DILEK OMER ET AL.: "Chiral 2-(2-hydroxyaryl)alcohols (HAROLs) with a 1, 4-diol scaffold as a new family of ligands and organocatalysts", TETRAHEDRON, vol. 74, 22 November 2017 (2017-11-22), pages 268 - 286, XP085317616, DOI: 10.1016/j.tet.2017.11.054
DILEK OMER ET AL.: "Chiral 2-(2-hydroxyaryl)alcohols (HAROLs) with a 1, 4-diol scaffold as a new family of ligands and organocatalysts", TETRAHEDRON, vol. 74, 22 November 2017 (2017-11-22), pages 268 - 286, XP085317616, DOI: 10.1016/j.tet.2017.11.054
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