Title:
METHOD FOR PREPARING M-TRIFLUOROMETHYLPHENOL
Document Type and Number:
WIPO Patent Application WO/2021/042721
Kind Code:
A1
Abstract:
Disclosed is a method for preparing m-trifluoromethylphenol. The present invention provides a method for preparing m-trifluoromethylphenol, which comprises the following steps: step (1): in a continuous flow reactor, subjecting an aqueous sulfate solution and an aqueous sodium nitrite solution to a diazotization reaction to obtain a diazonium salt solution, wherein the aqueous sulfate solution is a mixture of a sulfuric acid aqueous solution and m-trifluoromethyl aniline; and step (2): in the continuous flow reactor, subjecting the diazonium salt solution obtained in step (1) to a hydrolysis reaction in the presence of an aromatic solvent to obtain the m-trifluoromethylphenol, wherein the temperature of the hydrolysis reaction is 101ºC-200ºC. The continuous preparation method can increase the reaction concentration, greatly shorten the reaction time, improve the production efficiency and reduce safety risks; and the method can achieve a yield of 95% or more and a purity of 99.5% or more, is easy and simple to operate, and has the advantages of being safer, more environmentally friendly, of a lower cost, etc.
Inventors:
PAN QIANGBIAO (CN)
CHEN JINGHUA (CN)
ZHANG ZENGXING (CN)
LI JUNQI (CN)
CHEN JINGHUA (CN)
ZHANG ZENGXING (CN)
LI JUNQI (CN)
Application Number:
PCT/CN2020/083955
Publication Date:
March 11, 2021
Filing Date:
April 09, 2020
Export Citation:
Assignee:
ZHEJIANG WEIHUA NEW MAT CO LTD (CN)
International Classes:
C07C37/045; C07C39/24
Foreign References:
| CN110818533A | 2020-02-21 | |||
| CN106916052A | 2017-07-04 | |||
| CN106905096A | 2017-06-30 | |||
| CN101941890A | 2011-01-12 | |||
| US3914325A | 1975-10-21 | |||
| GB1433455A | 1976-04-28 | |||
| CN201910831538A | 2019-09-04 | |||
| CN106905096A | 2017-06-30 |
Other References:
TANIGUCHI TOSHIHIDE, IMOTO MITSUTAKA, TAKEDA MOTONORI, NAKAI TAKEO, MIHARA MASATOSHI, IWAI TOSHIYUKI, ITO TAKATOSHI, MIZUNO TAKUMI: "Hydrolysis of Diazonium Salts Using a Two-Phase System (CPME and Water)", HETEROATOM CHEMISTRY, JOHN WILEY & SONS, INC., US, vol. 26, no. 6, 1 November 2015 (2015-11-01), US, pages 411 - 416, XP055788280, ISSN: 1042-7163, DOI: 10.1002/hc.21275
JINSHA, CHENXIAOHUA, DU: "Continuous Synthesis of m-Trifluoromethylphenol in Microchannel Reactor [J", AGROCHEMICALS, vol. 56, no. 5, 2017, pages 320 - 323
JINSHA, CHENXIAOHUA, DU: "Continuous Synthesis of m-Trifluoromethylphenol in Microchannel Reactor [J", AGROCHEMICALS, vol. 56, no. 5, 2017, pages 320 - 323
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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