Title:
METHOD FOR PREPARING MESENCHYMAL STEM CELLS HAVING IMPROVED VIABILITY THROUGH ANTI-CANCER VIRUS INTRODUCTION
Document Type and Number:
WIPO Patent Application WO/2021/118325
Kind Code:
A1
Abstract:
The present invention relates to: a method for preparing mesenchymal stem cells, which have improved cell viability and contain an anti-cancer virus; a method for storing anti-cancer virus-introduced stem cells prepared by the method; and a cell therapeutic agent for treating cancer, containing anti-cancer virus-introduced stem cells prepared by the method. More specifically, anti-cancer virus infection efficiency is increased, replication time is prolonged, and lysis of stem cells by a virus is inhibited through the introduction of an anti-cancer virus into mesenchymal stem cells, followed by aspirin treatment, so that anti-cancer stem cells having excellent activity and improved viability and survival period can be prepared. In addition, an anti-cancer stem cell therapeutic agent prepared thereby can maintain a high survival rate during refrigeration through aspirin treatment, thereby being very medically and industrially valuable.
Inventors:
RA JEONG CHAN (KR)
KIM EUN-YOUNG (KR)
KIM EUN-YOUNG (KR)
Application Number:
PCT/KR2020/018272
Publication Date:
June 17, 2021
Filing Date:
December 14, 2020
Export Citation:
Assignee:
R BIO CO LTD (KR)
NATURECELL CO LTD (KR)
RA JEONG CHAN (KR)
NATURECELL CO LTD (KR)
RA JEONG CHAN (KR)
International Classes:
C12N5/0775; A61K35/28; A61P35/00
Domestic Patent References:
| WO2018021879A1 | 2018-02-01 |
Foreign References:
| US20190216855A1 | 2019-07-18 | |||
| KR20130117343A | 2013-10-25 | |||
| KR20130116213A | 2013-10-23 |
Other References:
EMILY K MADER, GREG BUTLER, SEAN C DOWDY, ANDREA MARIANI, KEITH L KNUTSON, MARK J FEDERSPIEL, STEPHEN J RUSSELL, EVANTHIA GALANIS,: "Optimizing patient derived mesenchymal stem cells as virus carriers for a Phase I clinical trial in ovarian cancer", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 11, no. 1, 20, 24 January 2013 (2013-01-24), pages 1 - 14, XP021139682, ISSN: 1479-5876, DOI: 10.1186/1479-5876-11-20
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
Download PDF: