Title:
METHOD FOR PREPARING MONTELUKAST SODIUM SALTS
Document Type and Number:
WIPO Patent Application WO/2010/036048
Kind Code:
A2
Abstract:
The present invention provides a method for preparing montelukast sodium salts of chemical formula 1 in the Description. The method of the present invention comprises the steps of: coupling the methanesulfonyl of chemical formula 2 and the compound of chemical formula 3 in the presence of bis(trimethylsilyl)amide alkali metal salts, adding an alkali metal base, and heating and hydrolyzing the resultant material to produce the compound of chemical formula 4; enabling a reaction between the compound of chemical formula 4 and 4-tert-butylcyclohexylamine and refining the resultant to produce the amine salts of chemical formula 5; and converting the amine salts into sodium salts.
Inventors:
LEE IN SANG (KR)
LEE SEOK JU (KR)
KANG JAE EUN (KR)
LEE SEOK JU (KR)
KANG JAE EUN (KR)
Application Number:
PCT/KR2009/005472
Publication Date:
April 01, 2010
Filing Date:
September 25, 2009
Export Citation:
Assignee:
LG LIFE SCIENCES LTD (KR)
LEE IN SANG (KR)
LEE SEOK JU (KR)
KANG JAE EUN (KR)
LEE IN SANG (KR)
LEE SEOK JU (KR)
KANG JAE EUN (KR)
International Classes:
C07D215/18
Domestic Patent References:
| WO2008072872A1 | 2008-06-19 | |||
| WO2008017669A1 | 2008-02-14 | |||
| WO2005105751A1 | 2005-11-10 | |||
| WO2006064269A2 | 2006-06-22 |
Foreign References:
| US20070208178A1 | 2007-09-06 |
Attorney, Agent or Firm:
SOHN, CHANG KYU (KR)
손창규 (KR)
손창규 (KR)
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