METHOD FOR PREPARING PANCREATIC BETA CELL, AND USE THEREOF

Title:

METHOD FOR PREPARING PANCREATIC BETA CELL, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2022/183740

Kind Code:

A1

Abstract:

The present invention relates to a method for preparing a differentiated pancreatic beta cell, and the use thereof. Specifically, the method comprises the following steps: (1) performing domesticated cultivation of pluripotent stem cells in a three-dimensional suspension manner; and (2) inducing the domesticated cells to differentiate into pancreatic beta cells. The present invention also relates to a method for preparing an alginate-polylysine-alginate (APA) microencapsulated artificial pancreas islet from the differentiated pancreatic beta cell. The method comprises preparing the microencapsulated artificial pancreas islet by means of using a sodium alginate solution. The present invention further relates to the use of the pancreatic beta cell and the artificial pancreas islet.

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Inventors:

YANG ZIJIANG (CN)
WANG HAO (CN)
ZHOU WEI (CN)
SU YIN (CN)

Application Number:

PCT/CN2021/124156

Publication Date:

September 09, 2022

Filing Date:

October 15, 2021

Export Citation:

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Assignee:

BETACURE MEDICAL INC (CN)

International Classes:

C12N5/071; A61K35/39; A61P3/10; C12N5/0735; C12N5/10

Foreign References:

CN112980771A	2021-06-18
CN106414718A	2017-02-15
CN109749986A	2019-05-14

Other References:

PAGLIUCA FELICIA W; MILLMAN JEFFREY R; GÜRTLER MADS; SEGEL MICHAEL; VAN DERVORT ALANA; RYU JENNIFER HYOJE; PETERSON QUINN P; GREIN: "Generation of Functional Human Pancreatic β Cells In Vitro", CELL, vol. 159, no. 2, 9 October 2014 (2014-10-09), Amsterdam NL , pages 428 - 439, XP029073423, ISSN: 0092-8674, DOI: 10.1016/j.cell.2014.09.040
TAN, MENGTIAN: "Differentiation of Human Pluripotent Stem Cells into Pancreatic Progenitor Cells", CHINESE DOCTORAL DISSERTATIONS FULL-TEXT DATABASE, 1 June 2019 (2019-06-01), CN, XP009539622, DOI: 10.27379/d.cnki.gwhdu.2019.000030

Attorney, Agent or Firm:

BEIJING HUIZHENG LAW OFFICE (CN)

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