Title:
METHOD FOR PREPARING QUINAZOLINE DERIVATIVE AND ANALOG THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/123883
Kind Code:
A1
Abstract:
A quinazoline derivative of general formula (I), a geometric isomer or a pharmaceutically acceptable salt thereof, and a preparation method therefor. The quinazoline derivative of general formula (I) can be used as a protein kinase inhibitor, particularly as a TRK inhibitor.
Inventors:
ZHAO DONGMEI (CN)
WU TIANXIAO (CN)
CHENG MAOSHENG (CN)
QIN QIAOHUA (CN)
LIU NIAN (CN)
ZHANG CHU (CN)
LV RUICHENG (CN)
HAO CHENZHOU (CN)
WU TIANXIAO (CN)
CHENG MAOSHENG (CN)
QIN QIAOHUA (CN)
LIU NIAN (CN)
ZHANG CHU (CN)
LV RUICHENG (CN)
HAO CHENZHOU (CN)
Application Number:
PCT/CN2022/098518
Publication Date:
July 06, 2023
Filing Date:
June 14, 2022
Export Citation:
Assignee:
UNIV SHENYANG PHARMACEUTICAL (CN)
International Classes:
C07D403/12; A61K31/506; A61P35/00
Domestic Patent References:
| WO2020118183A1 | 2020-06-11 | |||
| WO2002062789A1 | 2002-08-15 |
Other References:
UEHLING DAVID E., JOSEPH BABU, CHUNG KIM CHAN, ZHANG ANDREW X., LER SPENCER, PRAKESCH MICHAEL A., PODA GENNADY, GROULEFF JULIE, AM: "Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 15, 12 August 2021 (2021-08-12), US , pages 11129 - 11147, XP093076501, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.1c00506
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA SINICA (CN)
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