Title:
METHOD FOR PREPARING QUINOLONE COMPOUND AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/201780
Kind Code:
A1
Abstract:
Provided is a method for preparing a quinolone compound and an intermediate thereof, particularly, a method for preparing quinolone and a pharmaceutical quinolinone intermediate. Specifically, provided are a method for preparing a compound represented by formula I and a method for synthesizing a quinolone compound using the compound represented by formula I as an intermediate. The method for preparing the compound represented by formula I comprises the following step: reacting a compound represented by formula A with R5NH2 and R6Cl in the presence of a base to generate the compound represented by formula I.
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Inventors:
LEI JIE (CN)
CHEN ZHONGZHU (CN)
XU ZHIGANG (CN)
TANG DIANYONG (CN)
XU JIAYU (CN)
ZHOU HAOYI (CN)
XIA DANDAN (CN)
LIU YAO (CN)
CAO YIHUA (CN)
LUO JIE (CN)
CHEN ZHONGZHU (CN)
XU ZHIGANG (CN)
TANG DIANYONG (CN)
XU JIAYU (CN)
ZHOU HAOYI (CN)
XIA DANDAN (CN)
LIU YAO (CN)
CAO YIHUA (CN)
LUO JIE (CN)
Application Number:
PCT/CN2022/090989
Publication Date:
October 26, 2023
Filing Date:
May 05, 2022
Export Citation:
Assignee:
UNIV CHONGQING ARTS & SCIENCES (CN)
International Classes:
C07D215/233; C07D215/26; C07D215/38; C07D215/48; C07D215/56; C07D401/04; C07D471/04; C07D471/06; C07D491/056; C07D498/04; C07D498/06; C07D513/06; C07D519/00
Foreign References:
| CN105130892A | 2015-12-09 |
Other References:
ZHANG, ZHONG-WEI ET AL.: "Efficient Synthesis of 7H-Chromeno[3, 2-c]quinolin-5-ium Salts and Quinolin-4-ones through Acid-Promated Cascade Reaction of 3-Formylchromones and Anilines", CHEMISTRYSELECT, vol. 7, no. 7, 22 February 2022 (2022-02-22), XP093100695
IAROSHENKO VIKTOR O., MKRTCHYAN SATENIK, GEVORGYAN ASHOT, GRIGORYAN TATEVIK, VILLINGER ALEXANDER, LANGER PETER: "Synthesis of 4-quinolones, benzopyran derivatives and other fused systems based on the domino ANRORC reactions of (ortho-fluoro)-3-benzoylchromones", RSC ADVANCES, vol. 5, no. 36, 1 January 2015 (2015-01-01), pages 28717 - 28724, XP093102135, DOI: 10.1039/C5RA02978C
IAROSHENKO VIKTOR O., MKRTCHYAN SATENIK, GEVORGYAN ASHOT, GRIGORYAN TATEVIK, VILLINGER ALEXANDER, LANGER PETER: "Synthesis of 4-quinolones, benzopyran derivatives and other fused systems based on the domino ANRORC reactions of (ortho-fluoro)-3-benzoylchromones", RSC ADVANCES, vol. 5, no. 36, 1 January 2015 (2015-01-01), pages 28717 - 28724, XP093102135, DOI: 10.1039/C5RA02978C
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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