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Title:
METHOD FOR PREPARING SACUBITRIL INTERMEDIATE
Document Type and Number:
WIPO Patent Application WO/2023/029235
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of chemical synthesis and discloses a method for preparing a sacubitril intermediate. A key aza-tricyclic compound 5 is generated by using starting materials, chloramine-T trihydrate (formula 1) and an epoxypropane compound as shown in formula 2 which are simply and easily obtained, by means of a three-step reaction, then biphenyl is introduced by means of a Grignard reaction, then Ts on nitrogen is converted into a Boc group, and the preparation of the N-Boc amino alcohol compound of formula I can be completed. The whole method is simple to operate, safe and pollution-free, has no special requirements for equipment, has a low production cost, is suitable for industrial production, and has notable progress in comparison with the prior art.

Inventors:
MA BAODE (CN)
ZHENG YONGPENG (CN)
YU HONGYI (CN)
ZHAO JINHUI (CN)
XIAO YE (CN)
Application Number:
PCT/CN2021/132938
Publication Date:
March 09, 2023
Filing Date:
November 25, 2021
Export Citation:
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Assignee:
SHENZHEN CATALYS TECH CO LTD (CN)
International Classes:
C07C269/04
Domestic Patent References:
WO2017203474A12017-11-30
Foreign References:
CN111943862A2020-11-17
CN106397273A2017-02-15
CN105330569A2016-02-17
CN107382779A2017-11-24
CN106905192A2017-06-30
CN113135841A2021-07-20
CN109415308A2019-03-01
CN113387829A2021-09-14
CN110183357A2019-08-30
CN107540574A2018-01-05
CN108675943A2018-10-19
CN106496055A2017-03-15
CN107382785A2017-11-24
Attorney, Agent or Firm:
SHENZHEN LANFENG SHENGSHI INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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