Title:
METHOD FOR PREPARING SIALIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/193183
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a sialic acid derivative, wherein the method is characterized in that a process of using N-acetyl-D-glucosamine to prepare CMP-M-acetylneuraminic acid and a process of combining sialic acid with galactose or a galactose derivative to prepare a sialic acid (neuraminic acid) derivative are performed together in one reactor. According to the present invention, a high-priced cytidine 5'-monophosphoric acid (CMP) can be recycled in a reaction container, thereby reducing the amount of cytidine 5'-monophosphoric acid (CMP) introduced into the reaction, producing a sialic acid derivative using low-priced N-acetyl-D-glucosamine and pyruvic acid as substrates, and producing the sialic acid derivative at higher efficiency.
Inventors:
WOO JIN SUK (KR)
KIM BYUNG-GEE (KR)
KIM DAE HEE (KR)
CHOI YUN HEE (KR)
SONG JAE-KYUNG (KR)
KANG SUN YOUP (KR)
SEO WON MIN (KR)
YANG JI YOUNG (KR)
LEE SANG MI (KR)
KIM BYUNG-GEE (KR)
KIM DAE HEE (KR)
CHOI YUN HEE (KR)
SONG JAE-KYUNG (KR)
KANG SUN YOUP (KR)
SEO WON MIN (KR)
YANG JI YOUNG (KR)
LEE SANG MI (KR)
Application Number:
PCT/KR2014/004823
Publication Date:
December 04, 2014
Filing Date:
May 30, 2014
Export Citation:
Assignee:
GENECHEM INC (KR)
International Classes:
C12P19/00; C07H15/04; C07H15/20; C12N9/10
Domestic Patent References:
| WO1995026399A1 | 1995-10-05 |
Foreign References:
| KR100914525B1 | 2009-09-02 | |||
| JPH104961A | 1998-01-13 | |||
| JPH05211884A | 1993-08-24 | |||
| JPH03180190A | 1991-08-06 | |||
| JP2001136982A | 2001-05-22 | |||
| KR20060010706A | 2006-02-02 | |||
| KR100888513B1 | 2009-03-12 | |||
| KR20080055588A | 2008-06-19 |
Other References:
HAN,N.S. ET AL.: "Biotechnological production of human milk oligosaccharides.", BIOTECHNOLOGY ADVANCES., vol. 30, no. 6, 1 November 2012 (2012-11-01), pages 1268 - 1278, XP055074947, DOI: 10.1016/J.BIOTECHADV.2011.11.003
CHAPPELL,M.D. ET AL.: "Enzyme-Catalyzed Synthesis of Oligosaccharides That Contain Functionalized Sialic Acids.", J. AM. CHEM. SOC., vol. 119, no. 14, 1 April 1997 (1997-04-01), pages 3393 - 3394, XP055296953, DOI: 10.1021/JA963894P
See also references of EP 3009516A4
J. AM. CHEM. SOC., vol. 110, 1988, pages 6481
J. AM. CHEM. SOC., vol. 110, 1988, pages 7159
BIOTECHNOL. BIOENG., vol. 66, 1999, pages 2
ENZYME MICROB. TECHNOL., vol. 20, 1997
KIM, DAE-HEE, SUN MOON GRADUATE SCHOOL OF SCIENCE DOCTORAL DISSERTATION, 2011
"Protein Purification Techniques", 2001, OXFORD UNIVERSITY PRESS
CHAPPELL,M.D. ET AL.: "Enzyme-Catalyzed Synthesis of Oligosaccharides That Contain Functionalized Sialic Acids.", J. AM. CHEM. SOC., vol. 119, no. 14, 1 April 1997 (1997-04-01), pages 3393 - 3394, XP055296953, DOI: 10.1021/JA963894P
See also references of EP 3009516A4
J. AM. CHEM. SOC., vol. 110, 1988, pages 6481
J. AM. CHEM. SOC., vol. 110, 1988, pages 7159
BIOTECHNOL. BIOENG., vol. 66, 1999, pages 2
ENZYME MICROB. TECHNOL., vol. 20, 1997
KIM, DAE-HEE, SUN MOON GRADUATE SCHOOL OF SCIENCE DOCTORAL DISSERTATION, 2011
"Protein Purification Techniques", 2001, OXFORD UNIVERSITY PRESS
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
이처영 (KR)
이처영 (KR)
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