Title:
METHOD FOR PREPARING SUCRALOSE CRUDE PRODUCT BY USING ALCOHOL-WATER ALKALINE HYDROLYSIS SYSTEM
Document Type and Number:
WIPO Patent Application WO/2024/082156
Kind Code:
A1
Abstract:
The present invention provides a method for preparing a sucralose crude product by using an alcohol-water alkaline hydrolysis system, and relates to the technical field of fine chemical engineering. In the present invention, an aqueous solution of sucralose-6-acetate crude product is taken as a raw material, and is subjected to alkaline hydrolysis in an alkali metal hydroxide and methanol-water system, such that sucralose-6-acetate and chlorosucrose ester impurities (sucralose diester and tetrachlorosucrose-6-acetate) in the aqueous solution of sucralose-6-acetate crude product are both converted into sucralose, thereby significantly improving the yield of sucralose. In the present invention, separation is realized by carrying out multiple instances of concentration and multiple instances of extraction-back extraction in an ethyl acetate/water double-solvent system, such that fat-soluble impurities and water-soluble impurities are balanced in the system, and the phenomenon of saccharide coking during the concentration process can be avoided, thereby fully crystallizing sucralose in ethyl acetate, improving the yield of sucralose, efficiently separating inorganic salts from sucralose, and reducing the treatment cost of subsequent high-salinity wastewater.
Inventors:
CHEN YONGLE (CN)
QIU XIN (CN)
ZHAO CHENGCHENG (CN)
LI PENGFEI (CN)
QIU XIN (CN)
ZHAO CHENGCHENG (CN)
LI PENGFEI (CN)
Application Number:
PCT/CN2022/126051
Publication Date:
April 25, 2024
Filing Date:
October 19, 2022
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07H1/00; C07H1/06; C07H5/02
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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