Title:
METHOD FOR PREPARING SUCRALOSE CRUDE PRODUCT BY USING HYDROLYSIS SYSTEM
Document Type and Number:
WIPO Patent Application WO/2024/082177
Kind Code:
A1
Abstract:
The present invention provides a method for preparing a sucralose crude product by using an alcohol-water alkaline hydrolysis system, and relates to the technical field of fine chemical engineering. In the present invention, an aqueous solution comprising sucralose-6-acetate, sucralose diester and tetrachlorosucrose-6-acetate is used as a raw material solution, and is subjected to alkaline hydrolysis in an alkali metal hydroxide and water system, such that sucralose-6-acetate and chlorosucrose ester impurities (sucralose diester and tetrachlorosucrose-6-acetate) in the raw material solution can both be converted into sucralose, thereby significantly improving the yield of sucralose. In the present invention, separation is carried out by using multiple instances of concentration and multiple instances of extraction-back extraction of an ethyl acetate/water double-solvent system, such that fat-soluble impurities and water-soluble impurities are balanced in the system, and the phenomenon of saccharide coking during a concentration process can be avoided, thereby fully crystallizing sucralose in ethyl acetate, and improving the yield of sucralose.
Inventors:
CHEN YONGLE (CN)
SHEN DONGDONG (CN)
GUO SIYU (CN)
XIAO SHIDONG (CN)
SHEN DONGDONG (CN)
GUO SIYU (CN)
XIAO SHIDONG (CN)
Application Number:
PCT/CN2022/126186
Publication Date:
April 25, 2024
Filing Date:
October 19, 2022
Export Citation:
Assignee:
ANHUI JINHE IND CO LTD (CN)
International Classes:
C07H5/02; C07H1/00
Attorney, Agent or Firm:
BEIJING GAOWO LAW FIRM (CN)
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