METHOD FOR PREPARING SULFOBUTYL ETHER-Β-CYCLODEXTRIN

WIPO Patent Application WO/2015/103895

A1

Disclosed is a method for preparing sulfobutyl ether-β-cyclodextrin. The method overcomes shortcomings of the prior art; β-cyclodextrin and 1,4-sulfobutyrolactone are used as raw materials, and a proper amount of organic solvent is introduced into an alkaline aqueous solution, so that the solubility of the 1,4-sulfobutyrolactone is increased, and the synthesis rate of the sulfobutyl ether-β-cyclodextrin is improved. Operations, such as ultrasonic dialysis, active carbon decoloration, freezing and drying, are performed on the obtained product solution, so as to obtain the powder product of sulfobutyl ether-beta-cyclodextrin. The method has a stable process, needs a moderate reaction condition, has good selectivity, and needs simple aftertreatment operations; the obtained product has very high purity and yield, thereby providing a new idea and a method for mass production of sulfobutyl ether-β-cyclodextrin.

HONG HAO (CN)
LI CHANGFENG (CN)
SHEN LITAO (CN)

PCT/CN2014/088579

July 16, 2015

October 14, 2014

Click for automatic bibliography generation  

ASYMCHEM LAB TIANJIN CO LTD (CN)
ASYMCHEM LIFE SCIENCE TIANJIN CO LTD (CN)
TIANJIN ASYMCHEM PHARMACEUTICAL CO LTD (CN)
ASYMCHEM LAB FUXIN CO LTD (CN)
JILIN ASYMCHEM LAB CO LTD (CN)

C08B37/16

WO2013123254A1	2013-08-22
WO2013130666A1	2013-09-06

CN103694376A	2014-04-02
CN101959508A	2011-01-26
CN1858071A	2006-11-08
US5134127A	1992-07-28
US6153746A	2000-11-28

KANGXIN PARTNERS,P.C. (CN)
北京康信知识产权代理有限责任公司 (CN)

View/Download PDF      PDF Help

Previous Patent: TRAIL MEMBRANE-PENETRATING PEPTIDE-LIKE MUTANT, METHOD OF PREPARING SAME, AND USE THEREOF

Next Patent: ANTI-THEFT LOCKSET