Title:
METHOD FOR PREPARING TRABECTEDIN AND INTERMEDIATES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/219917
Kind Code:
A1
Abstract:
Provided in the present invention is a new method for preparing a trabectedin, using safracin B as the starting material and through a series of reactions synthesizing trabectedin. The method easily obtains raw materials, has fewer synthesis steps, does not use highly toxic organotin reagents, is safe and low-cost, and has high value in industrial applications.
Inventors:
ZHANG FULI (CN)
XU SHANGHU (CN)
WANG GUAN (CN)
LIN TANGHUAN (CN)
YU XUFENG (CN)
ZHU JINJIN (CN)
SHEN CHUANG (CN)
ZENG XIANGUO (CN)
CHAI JIAN (CN)
WU ZHONGWEI (CN)
YANG ZHIQING (CN)
XU SHANGHU (CN)
WANG GUAN (CN)
LIN TANGHUAN (CN)
YU XUFENG (CN)
ZHU JINJIN (CN)
SHEN CHUANG (CN)
ZENG XIANGUO (CN)
CHAI JIAN (CN)
WU ZHONGWEI (CN)
YANG ZHIQING (CN)
Application Number:
PCT/CN2017/088601
Publication Date:
December 28, 2017
Filing Date:
June 16, 2017
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI INST PHARMACEUTICAL IND (CN)
SHANGHAI INST PHARMACEUTICAL IND (CN)
International Classes:
C07D491/22; C07D471/18; C07D497/22
Foreign References:
CN103038240A | 2013-04-10 |
Other References:
XU SHANGHU: "A Concise and Practical Semisynthesis of Ecteinascidin 743 and (-)-Jorumycin", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2017, no. 5, 14 December 2016 (2016-12-14) - 6 February 2017 (2017-02-06), pages 975 - 983, XP055602016, ISSN: 1434-193X, DOI: 10.1002/ejoc.201601409
KORNVIKA CHARUPANT ET AL.: "Jorunnamycins A-C, new stabilized renieramycin-type bistetrahydroisoquinolines isolated from the Thai nudibranch Jorunna funebris", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 55, no. 1, January 2007 (2007-01-01) - 31 December 2007 (2007-12-31), pages 81 - 86, XP055602010
KORNVIKA CHARUPANT ET AL.: "Jorunnamycins A-C, new stabilized renieramycin-type bistetrahydroisoquinolines isolated from the Thai nudibranch Jorunna funebris", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 55, no. 1, January 2007 (2007-01-01) - 31 December 2007 (2007-12-31), pages 81 - 86, XP055602010
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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