Title:
METHOD FOR PREVENTING NITRATION OF TYROSINE RESIDUES IN HEPATOCYTE GROWTH FACTOR USING TRISULFIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/038088
Kind Code:
A1
Abstract:
The present invention provides a trisulfide-compound-containing agent for inhibiting nitration of tyrosine residues in hepatocyte growth factor, the trisulfide compound being: glutathione trisulfide or a pharmaceutically acceptable salt thereof; or a compound represented by formula (1) (wherein X represents -OR1 or -NR2R3, R1 represents a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, R2 and R3 independently represent a hydrogen atom or an alkyl group containing 1 to 6 carbon atoms, and the alkyl group may have one or more substituents selected from the group consisting of amino groups and carboxy groups), a pharmaceutically acceptable salt thereof, or a cyclodextrin clathrate thereof.
Inventors:
TATSUMI RYUICHI (JP)
NAKAMURA MAKO (JP)
OHSHIMA ETSUO (JP)
NAKAMURA MAKO (JP)
OHSHIMA ETSUO (JP)
Application Number:
PCT/JP2022/033764
Publication Date:
March 16, 2023
Filing Date:
September 08, 2022
Export Citation:
Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
KYOWA HAKKO BIO CO LTD (JP)
KYOWA HAKKO BIO CO LTD (JP)
International Classes:
A61K31/385; A61K38/06; A61P21/00; A61P43/00
Domestic Patent References:
| WO2018117186A1 | 2018-06-28 | |||
| WO2022045212A1 | 2022-03-03 | |||
| WO2021231476A1 | 2021-11-18 | |||
| WO2018117186A1 | 2018-06-28 |
Foreign References:
| CN113354615A | 2021-09-07 | |||
| JP2002087983A | 2002-03-27 |
Other References:
RYUICHI TATSUMI, FUNDAMENTAL SCIENCE OF MUSCLE STEM CELLS AND THEIR APPLICATIONS IN HEALTH AND MEDICINE, 14 March 2019 (2019-03-14)
A. ELGAABARI ET AL.: "Insight linking between nitration and myogenic dysfunction of HGF/NK1 domain", THE 128TH ANNUAL MEETING OF JAPANESE SOCIETY OF ANIMAL SCIENCE
R. TATSUMI: "Mechano-biology of skeletal muscle hypertrophy and regeneration: possible mechanism of stretch-induced activation of resident myogenic stem cells", ANIMAL SCIENCE JOURNAL, vol. 81, no. 1, 2010, pages 11 - 20, XP055104184, DOI: 10.1111/j.1740-0929.2009.00712.x
NANA IMATOMI ET AL.: "Physiologic significance of nitrated/dysfunction of myogenic stem satellite cell activator HGF: breakthrough of major factors for age-related muscle atrophy with impaired regeneration", THE 128TH ANNUAL MEETING OF JAPANESE SOCIETY OF ANIMAL SCIENCE
T. IDA ET AL.: "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling", PNAS, vol. 111, no. 21, 27 May 2014 (2014-05-27), pages 7606 - 7611, XP055443522, DOI: 10.1073/pnas.1321232111
HIROHITO TSUBOUCHI: "Discovery and clinical application of hepatocyte growth factor", JOURNAL OF JAPANESE SOCIETY OF GASTROENTEROLOGY, vol. 110, no. 12, 2013, pages 2033 - 2041
SHINYA MIZUNOTOSHIKAZU NAKAMURA: "Clinical application of HGF, a tissue repair factor", DRUG DELIVERY SYSTEM, 2001, pages 16 - 6
C. DESOLE ET AL.: "HGF and MET: From Brain Development to Neurological Disorders", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 9, 9 June 2021 (2021-06-09)
A. ELGAABARI: "A pilot study on nitration/dysfunction of NK.1 segment of myogenic stem cell activator HGF", BIOCHEMISTRY AND BIOPHYSICS REPORTS, vol. 31, 2022, pages 101295
A. ELGAABARI ET AL.: "Insight linking between nitration and myogenic dysfunction of HGF/NK1 domain", THE 128TH ANNUAL MEETING OF JAPANESE SOCIETY OF ANIMAL SCIENCE
R. TATSUMI: "Mechano-biology of skeletal muscle hypertrophy and regeneration: possible mechanism of stretch-induced activation of resident myogenic stem cells", ANIMAL SCIENCE JOURNAL, vol. 81, no. 1, 2010, pages 11 - 20, XP055104184, DOI: 10.1111/j.1740-0929.2009.00712.x
NANA IMATOMI ET AL.: "Physiologic significance of nitrated/dysfunction of myogenic stem satellite cell activator HGF: breakthrough of major factors for age-related muscle atrophy with impaired regeneration", THE 128TH ANNUAL MEETING OF JAPANESE SOCIETY OF ANIMAL SCIENCE
T. IDA ET AL.: "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling", PNAS, vol. 111, no. 21, 27 May 2014 (2014-05-27), pages 7606 - 7611, XP055443522, DOI: 10.1073/pnas.1321232111
HIROHITO TSUBOUCHI: "Discovery and clinical application of hepatocyte growth factor", JOURNAL OF JAPANESE SOCIETY OF GASTROENTEROLOGY, vol. 110, no. 12, 2013, pages 2033 - 2041
SHINYA MIZUNOTOSHIKAZU NAKAMURA: "Clinical application of HGF, a tissue repair factor", DRUG DELIVERY SYSTEM, 2001, pages 16 - 6
C. DESOLE ET AL.: "HGF and MET: From Brain Development to Neurological Disorders", FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 9, 9 June 2021 (2021-06-09)
A. ELGAABARI: "A pilot study on nitration/dysfunction of NK.1 segment of myogenic stem cell activator HGF", BIOCHEMISTRY AND BIOPHYSICS REPORTS, vol. 31, 2022, pages 101295
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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