Title:
A METHOD FOR PREVENTING, REDUCING, AND TREATING RADIATION CYSTITIS USING HYALURONIC ACID
Document Type and Number:
WIPO Patent Application WO2000024387
Kind Code:
A3
Abstract:
A method for preventing, reducing or treating radiation cystitis caused by external beam radiation therapy, which impinges on the urinary bladder and associated structures, comprising administering into the urinary bladder and associated structures a composition comprising hyaluronic acid (HA) having an average molecular weight of not less than 2 X 10<5> Daltons and a pharmaceutically acceptable carrier.
Inventors:
POMMERVILLE PETER J (CA)
Application Number:
PCT/CA1999/000994
Publication Date:
August 03, 2000
Filing Date:
October 22, 1999
Export Citation:
Assignee:
BIONICHE INC (CA)
POMMERVILLE PETER J (CA)
POMMERVILLE PETER J (CA)
International Classes:
A61K31/728; A61P13/10; (IPC1-7): A61K31/728; A61P17/16
Domestic Patent References:
| WO1996025168A1 | 1996-08-22 | |||
| WO1997003699A1 | 1997-02-06 |
Foreign References:
| CA2247389A1 | 1998-07-09 | |||
| US5880108A | 1999-03-09 |
Other References:
PORRU DANIELE; CAMPUS GIULIANA; TUDINO DONATELLA; VALDES ENRICO; VESPA ALESSANDRO; SCARPA ROBERTO M; USAI ENZO: "Results of treatment of refractory interstitial cystitis with intravesical hyaluronic acid.", UROLOGIA INTERNATIONALIS, vol. 59, no. 1, 1997, pages 26 - 29, XP000908835
LIGUORI VINCENZO; GUILLEMIN CLAIRE; PESCE GIAN F; MIRIMANOFF RENE O; BERNIER JACQUES: "Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy.", RADIOTHERAPY AND ONCOLOGY, vol. 42, no. 2, 1997, pages 155 - 161, XP000908841
DOWNEY JOE; NICKEL J CURTIS; MORALES ALVARO; EMERSON LAUREL; CLARK JANET: "Relative efficacy of various exogenous glycosaminoglycans in providing a bladder surface permeability barrier.", JOURNAL OF UROLOGY, vol. 157, no. 4 Suppl., 1997, pages 128, XP000908840
STROHMAIER W.L.: "Therapie der Interstitiellen Bzm. Radiogenen Zystitis mit D Glukosamin", HEL. CHIR. ACTA, vol. 56, 1989, pages 323 - 325, XP000908833
LIGUORI VINCENZO; GUILLEMIN CLAIRE; PESCE GIAN F; MIRIMANOFF RENE O; BERNIER JACQUES: "Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy.", RADIOTHERAPY AND ONCOLOGY, vol. 42, no. 2, 1997, pages 155 - 161, XP000908841
DOWNEY JOE; NICKEL J CURTIS; MORALES ALVARO; EMERSON LAUREL; CLARK JANET: "Relative efficacy of various exogenous glycosaminoglycans in providing a bladder surface permeability barrier.", JOURNAL OF UROLOGY, vol. 157, no. 4 Suppl., 1997, pages 128, XP000908840
STROHMAIER W.L.: "Therapie der Interstitiellen Bzm. Radiogenen Zystitis mit D Glukosamin", HEL. CHIR. ACTA, vol. 56, 1989, pages 323 - 325, XP000908833
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