METHOD FOR THE PREVENTION OF MALARIA

Title:

METHOD FOR THE PREVENTION OF MALARIA

Document Type and Number:

WIPO Patent Application WO2004045559

Kind Code:

A3

Abstract:

The invention comprises a novel method for protecting subjects against malaria. The method of the invention involves inoculation with attenuated sporozoites, and in particular, but not limited to subcutaneous, intramuscular, intradermal, mucosal, submucosal, and cutaneous administration.

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Inventors:

HOFFMAN STEPHEN L (US)
LUKE THOMAS C (US)

Application Number:

PCT/US2003/037498

Publication Date:

August 12, 2004

Filing Date:

November 20, 2003

Export Citation:

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Assignee:

HOFFMAN STEPHEN L (US)
LUKE THOMAS C (US)

International Classes:

A61K39/00; A61K39/002; A61K39/015; G01N33/536; A61K; (IPC1-7): G01N33/536

Other References:

COLLINS, W. E. ET AL.: "Potential of the Panama Strain of Plasmodium vivax for the Testing of Malarial Vaccines in Aotus Nancymai Monkeys", AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, vol. 67, no. 5, 2002, pages 454 - 458, XP002976724
ZAPATA, J. C. ET AL.: "Reproducible infection of intact aotus lemurinus griseimembra monkeys by plasmodium falciparum sporozoite inoculation", JOURNAL OF PARASITOLOGY, vol. 88, no. 4, August 2002 (2002-08-01), pages 723 - 729, XP002976725
SCHOFIELD ET AL.: "Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria", NATURE, vol. 418, August 2002 (2002-08-01), pages 785 - 789, XP002239679

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