Title:
METHOD FOR PRODUCING 2'-MODIFIED GUANOSINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/027065
Kind Code:
A1
Abstract:
The present invention provides a novel method for producing a 2'-modified guanosine compound represented by the formula. In the formula, R1 and R2 may be the same or different, and each represents a hydrogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C7-16 aralkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C2-6 alkynyl group or an optionally substituted C6-14 aryl group; n represents 0 or 1; in cases where n is 1, P1 represents a protecting group which is bonded to a nitrogen atom with a single bond; and in cases where n is 0, P1 represents a protecting group which is bonded to a nitrogen atom with a double bond.
Inventors:
UMEDA YASUHIRO (JP)
MIMORI YUJI (JP)
MORODOME KEISUKE (JP)
MATSUOKA SEIYA (JP)
MIMORI YUJI (JP)
MORODOME KEISUKE (JP)
MATSUOKA SEIYA (JP)
Application Number:
PCT/JP2022/031705
Publication Date:
March 02, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
NISSAN CHEMICAL CORP (JP)
International Classes:
C07H19/167; A61K31/708; A61P43/00
Domestic Patent References:
| WO2007102581A1 | 2007-09-13 |
Foreign References:
| JPH072889A | 1995-01-06 | |||
| JP5194256B2 | 2013-05-08 |
Other References:
TAKESHI YAMADA, NATSUKI OKANIWA, HISAO SANEYOSHI, AKIHIRO OHKUBO, KOHJI SEIO, TETSUYA NAGATA, YOSHITSUGU AOKI, SHIN’ICHI TAK: "Synthesis of 2′- O -[2-( N -Methylcarbamoyl)ethyl]ribonucleosides Using Oxa-Michael Reaction and Chemical and Biological Properties of Oligonucleotide Derivatives Incorporating These Modified Ribonucleosides", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 76, no. 9, 6 May 2011 (2011-05-06), pages 3042 - 3053, XP055621126, ISSN: 0022-3263, DOI: 10.1021/jo101963z
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 76, 2011, pages 3042
T. W. GREENE: "Protective Groups in Organic Synthesis", 2006, JOHN WILEY & SONS INC.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, 2012, pages 4127 - 4132
THE JOURNAL OF ORGANIC CHEMISTRY, vol. 76, 2011, pages 3042
T. W. GREENE: "Protective Groups in Organic Synthesis", 2006, JOHN WILEY & SONS INC.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, 2012, pages 4127 - 4132
Attorney, Agent or Firm:
HANABUSA PATENT & TRADEMARK OFFICE (JP)
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