Title:
METHOD FOR PRODUCING 225AC SOLUTION
Document Type and Number:
WIPO Patent Application WO/2022/014555
Kind Code:
A1
Abstract:
This method for producing a 225Ac solution comprises steps (I)-(III). In step (I), a solution (1) containing 226Ra and 225Ac is passed through a solid-phase extractant (a) containing a compound represented by formula (A), and 225Ac is held in the solid-phase extractant (a). In step (II), a liquid, which contains an eluate (2) obtained by eluting the held 225Ac from the solid-phase extractant (a), is passed through a solid-phase extractant (b) containing a compound represented by formula (B), and 225Ac is held in the solid-phase extractant (b). In step (III), the held 225Ac is eluted from the solid-phase extractant (b) to obtain a 225Ac solution. (A) [m and n are each independently 0 or 1, and R1-R4 are each independently a C8-C12 alkyl group.] (B) [R5-R6 are each independently a C8 alkyl group or a C8 alkoxy group.]
Inventors:
HONDA YOSHIO (JP)
NATSUSAKO MASASHI (JP)
ASO SHUNICHI (JP)
NATSUSAKO MASASHI (JP)
ASO SHUNICHI (JP)
Application Number:
PCT/JP2021/026222
Publication Date:
January 20, 2022
Filing Date:
July 13, 2021
Export Citation:
Assignee:
NIHON MEDIPHYSICS CO LTD (JP)
International Classes:
G21G4/08; A61K51/00; B01J20/22; B01J20/34; C22B3/24; C22B60/02
Domestic Patent References:
| WO2021002275A1 | 2021-01-07 |
Foreign References:
| JP2009527731A | 2009-07-30 | |||
| US20150292061A1 | 2015-10-15 |
Other References:
OSTAPENKO, V. ET AL.: "Extraction chromatographic behavior of actinium and REE on DGA, Ln and TRU resins in nitric acid solutions", JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, vol. 306, 2015, pages 707 - 711, XP035920725, ISSN: 1558-2780, DOI: https://doi.org/10.1007/s10967-015-4331-y
MAERTENS D., J. MERMANS, S. HEINITZ, T. CARDINAELS: "Ra-226/Ac-225 chemical separation R&D at SCK-CEN", 11TH INTERNATIONAL SYMPOSIUM ON TARGETED ALPHA THERAPY, 4 January 2019 (2019-01-04), XP055947293
MCALISTER DANIEL R., HORWITZ E. PHILIP: "Characterization of Extraction of Chromatographic Materials Containing Bis(2‐ethyl‐1‐hexyl)Phosphoric Acid, 2‐Ethyl‐1‐Hexyl (2‐Ethyl‐1‐Hexyl) Phosphonic Acid, and Bis(2,4,4‐Trimethyl‐1‐Pentyl)Phosphinic Acid", SOLVENT EXTRACTION AND ION EXCHANGE, vol. 25, no. 6, 1 October 2007 (2007-10-01), US , pages 757 - 769, XP093065273, ISSN: 0736-6299, DOI: 10.1080/07366290701634594
See also references of EP 4184528A4
MAERTENS D., J. MERMANS, S. HEINITZ, T. CARDINAELS: "Ra-226/Ac-225 chemical separation R&D at SCK-CEN", 11TH INTERNATIONAL SYMPOSIUM ON TARGETED ALPHA THERAPY, 4 January 2019 (2019-01-04), XP055947293
MCALISTER DANIEL R., HORWITZ E. PHILIP: "Characterization of Extraction of Chromatographic Materials Containing Bis(2‐ethyl‐1‐hexyl)Phosphoric Acid, 2‐Ethyl‐1‐Hexyl (2‐Ethyl‐1‐Hexyl) Phosphonic Acid, and Bis(2,4,4‐Trimethyl‐1‐Pentyl)Phosphinic Acid", SOLVENT EXTRACTION AND ION EXCHANGE, vol. 25, no. 6, 1 October 2007 (2007-10-01), US , pages 757 - 769, XP093065273, ISSN: 0736-6299, DOI: 10.1080/07366290701634594
See also references of EP 4184528A4
Attorney, Agent or Firm:
SSINPAT PATENT FIRM (JP)
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