Title:
METHOD FOR PRODUCING 2,4-DIALKYLBENZALDEHYDE
Document Type and Number:
WIPO Patent Application WO/2021/075518
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing 2,4-dialkylbenzaldehyde having an excellent conversion rate, an excellent yield, and excellent regioselectivity of formylation, the method comprising causing carbon monoxide to act on a reaction raw material containing specific m-dialkylbenzene in the presence of hydrogen fluoride and boron trifluoride. A method for producing 2,4-dialkylbenzaldehyde according to the present invention comprises a step for formylating at least a position (a) by causing carbon monoxide to act on a reaction raw material containing m-dialkylbenzene represented by formula (1) in the presence of hydrogen fluoride and boron trifluoride, wherein the reaction raw material is dialkylbenzene containing greater than 90 mol% of the m-dialkylbenzene represented by formula (1), and the number of moles of boron trifluoride with respect to 1 mole of the m-dialkylbenzene represented by formula (1) is 0.7-0.3. (In the formula, R1 represents a C1-C3 alkyl group, and R2 represents a C2-C7 chain or cyclic alkyl group having secondary or tertiary carbon at a benzylic position. Here, the number of carbon atoms in R2 is larger than the number of carbon atoms in R1.)
Inventors:
SHISHIMI TORU (JP)
UTAMURA TATSUYA (JP)
MATSUURA YUTAKA (JP)
NAGAO SHINICHI (JP)
UTAMURA TATSUYA (JP)
MATSUURA YUTAKA (JP)
NAGAO SHINICHI (JP)
Application Number:
PCT/JP2020/039007
Publication Date:
April 22, 2021
Filing Date:
October 16, 2020
Export Citation:
Assignee:
MITSUBISHI GAS CHEMICAL CO (JP)
International Classes:
C07C45/49; C07C47/542
Foreign References:
| JP2005120037A | 2005-05-12 | |||
| JP2004043362A | 2004-02-12 | |||
| JP2017533926A | 2017-11-16 | |||
| JPS505344A | 1975-01-21 | |||
| JPH06234692A | 1994-08-23 | |||
| JP2005120037A | 2005-05-12 |
Other References:
GROUNSE, NATHAN N.: "The Gattermann-Koch Reaction. The Formylation of Isopropylbenzene under Pressure", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 71, no. 4, 1 April 1949 (1949-04-01), pages 1263 - 1264, XP055818366
See also references of EP 4046986A4
See also references of EP 4046986A4
Attorney, Agent or Firm:
OHTANI PATENT OFFICE (JP)
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