Title:
METHOD FOR PRODUCING 4-HYDROXYBENZOIC ACID
Document Type and Number:
WIPO Patent Application WO/2023/120538
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for producing 4-hydroxybenzoic acid (4HBA) with high efficiency from a starting material such as a biomass, and provides a method for producing 4-hydroxybenzoic acid which includes the following steps (1) and (2). Step (1): a step for preparing an aqueous solution containing coumaric acid and ferulic acid; and step (2): a step for allowing a bacterium in which the expression of PobA enzyme is defective to act on the aqueous solution prepared in step (1) to metabolize the ferulic acid as a growth carbon source by the bacterium and convert the coumaric acid to 4-hydroxybenzoic acid by the bacterium.
Inventors:
TSURUYA ATSUKI (JP)
KURIHARA HIROYUKI (JP)
SONOKI TOMONORI (JP)
HIGUCHI YUDAI (JP)
KURIHARA HIROYUKI (JP)
SONOKI TOMONORI (JP)
HIGUCHI YUDAI (JP)
Application Number:
PCT/JP2022/046954
Publication Date:
June 29, 2023
Filing Date:
December 20, 2022
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
UNIV HIROSAKI (JP)
UNIV HIROSAKI (JP)
International Classes:
C12P7/42; C12N1/21
Domestic Patent References:
| WO2017170549A1 | 2017-10-05 |
Foreign References:
| JP2016526896A | 2016-09-08 |
Other References:
VERHOEF, S. RUIJSSENAARS, H.J. DE BONT, J.A.M. WERY, J.: "Bioproduction of p-hydroxybenzoate from renewable feedstock by solvent-tolerant Pseudomonas putida S12", JOURNAL OF BIOTECHNOLOGY, ELSEVIER, AMSTERDAM NL, vol. 132, no. 1, 5 October 2007 (2007-10-05), Amsterdam NL , pages 49 - 56, XP022285747, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2007.08.031
WADA AYUMU, PRATES ÉRICA T., HIRANO RYO, WERNER ALLISON Z., KAMIMURA NAOFUMI, JACOBSON DANIEL A., BECKHAM GREGG T., MASAI EIJI: "Characterization of aromatic acid/proton symporters in Pseudomonas putida KT2440 toward efficient microbial conversion of lignin-related aromatics", METABOLIC ENGINEERING, ACADEMIC PRESS, AMSTERDAM, NL, vol. 64, 1 March 2021 (2021-03-01), AMSTERDAM, NL, pages 167 - 179, XP093073986, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2021.01.013
NONAKA KAZUHIRO, OHTA HIROYUKI, SATO YOSHINORI, HOSOKAWA KEIICHI: "Utilization of Phenylpropanoids by Pseudomonas putida Soil Isolates and Its Probable Taxonomic Significance", MICROBES AND ENVIRONMENTS, vol. 23, no. 4, 1 January 2008 (2008-01-01), pages 360 - 364, XP093073993, ISSN: 1342-6311, DOI: 10.1264/jsme2.ME08545
AKUTSU, MIHO; KAMIMURA, NAOHUMI; MASAI, EIJI; SONOKI, TOMONORI: "2A16a13 Application of Pseudomonas sp. NGC7 to the production of 4-hydroxybenzoic acid from lignin", ANNUAL MEETING OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY (JSBBA2020); MARCH 25 - 28, 2020, vol. 2020, 1 January 2020 (2020-01-01) - 28 March 2020 (2020-03-28), pages 272, XP009547239
WANG WEI, CHEN XIAOWEN, KATAHIRA RUI, TUCKER MELVIN: "Characterization and Deconstruction of Oligosaccharides in Black Liquor From Deacetylation Process of Corn Stover", FRONTIERS IN ENERGY RESEARCH, vol. 7, XP093073997, DOI: 10.3389/fenrg.2019.00054
CHRISTOPHER W. JOHNSON, ET AL.: "Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity", METABOLIC ENGINEERING COMMUNICATIONS, ELSEVIER, NL, vol. 3, 1 December 2016 (2016-12-01), NL , pages 111 - 119, XP055537131, ISSN: 2214-0301, DOI: 10.1016/j.meteno.2016.04.002
XU, F. SUN, R.C. SUN, J.X. LIU, C.F. HE, B.H. FAN, J.S.: "Determination of cell wall ferulic and p-coumaric acids in sugarcane bagasse", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 552, no. 1-2, 3 November 2005 (2005-11-03), AMSTERDAM, NL , pages 207 - 217, XP005116955, ISSN: 0003-2670, DOI: 10.1016/j.aca.2005.07.037
KARLEN STEVEN D., FASAHATI PEYMAN, MAZAHERI MONA, SERATE JOSE, SMITH REBECCA A., SIROBHUSHANAM SIRISHA, CHEN MINGJIE, TYMOKHIN VIT: "Assessing the Viability of Recovery of Hydroxycinnamic Acids from Lignocellulosic Biorefinery Alkaline Pretreatment Waste Streams", CHEMSUSCHEM, WILEY-VCH, DE, vol. 13, no. 8, 21 April 2020 (2020-04-21), DE , pages 2012 - 2024, XP093074000, ISSN: 1864-5631, DOI: 10.1002/cssc.201903345
WADA AYUMU, PRATES ÉRICA T., HIRANO RYO, WERNER ALLISON Z., KAMIMURA NAOFUMI, JACOBSON DANIEL A., BECKHAM GREGG T., MASAI EIJI: "Characterization of aromatic acid/proton symporters in Pseudomonas putida KT2440 toward efficient microbial conversion of lignin-related aromatics", METABOLIC ENGINEERING, ACADEMIC PRESS, AMSTERDAM, NL, vol. 64, 1 March 2021 (2021-03-01), AMSTERDAM, NL, pages 167 - 179, XP093073986, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2021.01.013
NONAKA KAZUHIRO, OHTA HIROYUKI, SATO YOSHINORI, HOSOKAWA KEIICHI: "Utilization of Phenylpropanoids by Pseudomonas putida Soil Isolates and Its Probable Taxonomic Significance", MICROBES AND ENVIRONMENTS, vol. 23, no. 4, 1 January 2008 (2008-01-01), pages 360 - 364, XP093073993, ISSN: 1342-6311, DOI: 10.1264/jsme2.ME08545
AKUTSU, MIHO; KAMIMURA, NAOHUMI; MASAI, EIJI; SONOKI, TOMONORI: "2A16a13 Application of Pseudomonas sp. NGC7 to the production of 4-hydroxybenzoic acid from lignin", ANNUAL MEETING OF JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY (JSBBA2020); MARCH 25 - 28, 2020, vol. 2020, 1 January 2020 (2020-01-01) - 28 March 2020 (2020-03-28), pages 272, XP009547239
WANG WEI, CHEN XIAOWEN, KATAHIRA RUI, TUCKER MELVIN: "Characterization and Deconstruction of Oligosaccharides in Black Liquor From Deacetylation Process of Corn Stover", FRONTIERS IN ENERGY RESEARCH, vol. 7, XP093073997, DOI: 10.3389/fenrg.2019.00054
CHRISTOPHER W. JOHNSON, ET AL.: "Enhancing muconic acid production from glucose and lignin-derived aromatic compounds via increased protocatechuate decarboxylase activity", METABOLIC ENGINEERING COMMUNICATIONS, ELSEVIER, NL, vol. 3, 1 December 2016 (2016-12-01), NL , pages 111 - 119, XP055537131, ISSN: 2214-0301, DOI: 10.1016/j.meteno.2016.04.002
XU, F. SUN, R.C. SUN, J.X. LIU, C.F. HE, B.H. FAN, J.S.: "Determination of cell wall ferulic and p-coumaric acids in sugarcane bagasse", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 552, no. 1-2, 3 November 2005 (2005-11-03), AMSTERDAM, NL , pages 207 - 217, XP005116955, ISSN: 0003-2670, DOI: 10.1016/j.aca.2005.07.037
KARLEN STEVEN D., FASAHATI PEYMAN, MAZAHERI MONA, SERATE JOSE, SMITH REBECCA A., SIROBHUSHANAM SIRISHA, CHEN MINGJIE, TYMOKHIN VIT: "Assessing the Viability of Recovery of Hydroxycinnamic Acids from Lignocellulosic Biorefinery Alkaline Pretreatment Waste Streams", CHEMSUSCHEM, WILEY-VCH, DE, vol. 13, no. 8, 21 April 2020 (2020-04-21), DE , pages 2012 - 2024, XP093074000, ISSN: 1864-5631, DOI: 10.1002/cssc.201903345
Attorney, Agent or Firm:
MIYAJIMA Manabu et al. (JP)
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