METHOD FOR PRODUCING 4(3H)-QUINAZOLINONE DERIVATIVE

Title:

METHOD FOR PRODUCING 4(3H)-QUINAZOLINONE DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/2007/004735

Kind Code:

A1

Abstract:

Disclosed is a method for producing 2-methyl-3-{4- [3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone comprising a step for reacting 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazine-4-one with 4-[3-(1-pirrolidinyl)propoxy]aniline or an acid addition salt thereof, or 4-(1-cyclobutyl-4-piperidinyl)oxyaniline or an acid addition salt thereof in the presence of an acetic acid catalyst.

Inventors:

SAWADA NAOTAKA (JP)
TSURITANI TAKAYUKI (JP)
SATO KIMIHIKO (JP)
ITOH TAKAHIRO (JP)
AKAO ATSUSHI (JP)
KADOWAKI CHIE (JP)
IIDA TAKEHIKO (JP)
YASUDA NOBUYOSHI (JP)
MASE TOSHIAKI (JP)

Application Number:

PCT/JP2006/313639

Publication Date:

January 11, 2007

Filing Date:

July 04, 2006

Export Citation:

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Assignee:

BANYU PHARMA CO LTD (JP)
SAWADA NAOTAKA (JP)
TSURITANI TAKAYUKI (JP)
SATO KIMIHIKO (JP)
ITOH TAKAHIRO (JP)
AKAO ATSUSHI (JP)
KADOWAKI CHIE (JP)
IIDA TAKEHIKO (JP)
YASUDA NOBUYOSHI (JP)
MASE TOSHIAKI (JP)

International Classes:

C07D403/12

Domestic Patent References:

WO2005077905A1	2005-08-25
WO2006085692A1	2006-08-17
WO2005077905A1	2005-08-25

Foreign References:

JPS55122781A	1980-09-20
JPH08104675A	1996-04-23

Other References:

SINGH S.K. ET AL.: "Synthesis of 5-(trifluoromethyl)-5,8-didazafolic acid and 5-(trifluoromethyl)-5,8-dideazaisofolic acid", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 27, no. 7, 1990, pages 2101 - 2105, XP003002164
See also references of EP 1903040A4

Attorney, Agent or Firm:

BANYU PHARMACEUTICAL CO., LTD. (1-13-12 Kudankit, Chiyoda-ku Tokyo, JP)

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