Title:
METHOD FOR PRODUCING ACTIVE PHARMACEUTICAL INGREDIENT OF BIOPHARMACEUTICAL, SYSTEM FOR PRODUCING ACTIVE PHARMACEUTICAL INGREDIENT OF BIOPHARMACEUTICAL, AND ACTIVE PHARMACEUTICAL INGREDIENT OF BIOPHARMACEUTICAL
Document Type and Number:
WIPO Patent Application WO/2023/188937
Kind Code:
A1
Abstract:
A culturing unit for performing a culture step for culturing cells in culture broth retained in a culture tank and removing the cells from the culture broth to thereby obtain a culture supernatant containing a product of the cells, and a purification unit for performing a purification step for purifying the product from the culture supernatant to thereby obtain an active pharmaceutical ingredient of a biopharmaceutical, are connected by a connecting line. The culture supernatant is allowed to flow through the connecting line from the culturing unit to the purification unit. A flexible single-use tank having a capacity of 0.2 to 10 times the volume of the culture broth in the culture tank is joined to a branch line provided between the culturing unit and the purification unit. The culture supernatant is temporarily retained in the tank.
Inventors:
NAKAI SHINICHI (JP)
SAKUYAMA HIROSHI (JP)
TAKAHASHI NAOTO (JP)
SAKUYAMA HIROSHI (JP)
TAKAHASHI NAOTO (JP)
Application Number:
PCT/JP2023/005301
Publication Date:
October 05, 2023
Filing Date:
February 15, 2023
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C12M1/00; C12M3/00; C12P21/02; C12P21/08
Domestic Patent References:
| WO2020152509A1 | 2020-07-30 |
Foreign References:
| JP2013544524A | 2013-12-19 | |||
| US20210355428A1 | 2021-11-18 | |||
| JP2017515501A | 2017-06-15 | |||
| JP2018525219A | 2018-09-06 |
Attorney, Agent or Firm:
TAIYO, NAKAJIMA & KATO (JP)
Download PDF:
Previous Patent: ELECTROCHEMICAL CELL
Next Patent: INFORMATION PROCESSING DEVICE AND INFORMATION PROCESSING METHOD
Next Patent: INFORMATION PROCESSING DEVICE AND INFORMATION PROCESSING METHOD