Title:
METHOD FOR PRODUCING AMIDE BOND-CONTAINING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/192488
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing an amide bond-containing compound with which an active acid raw material having an aromatic heterocycle to which a carbonyl group is bonded can be easily removed. This method for producing an amide bond-containing compound includes, in a reaction via a liquid phase method, step A for synthesizing an amide bond-containing compound by reacting a reactive amine raw material with a compound (an active acid raw material) obtained by esterifying, acid-halogenating, or acid-anhydridizing a carboxylic acid having an aromatic heterocycle to which a carbonyl group is bonded; step B for mixing a specific inducing agent and a monoamine compound with a reaction mixture obtained in step A to thereby react the active acid raw material and the inducing agent; and step C for washing the reaction mixture obtained in step B with a basic and/or acidic aqueous solution.
Inventors:
MURATA TAKAHIKO (JP)
NISHIYAMA AKIRA (JP)
YAMAMOTO SHOHEI (JP)
NISHIYAMA AKIRA (JP)
YAMAMOTO SHOHEI (JP)
Application Number:
PCT/JP2021/000531
Publication Date:
September 30, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C07D207/34; C07D403/12; C07D409/12; C07D417/12
Domestic Patent References:
| WO2009014176A1 | 2009-01-29 |
Foreign References:
| JP2003055396A | 2003-02-26 | |||
| JP2003073396A | 2003-03-12 |
Other References:
KAWASHIMA, ETSUKO ET AL., YAKUGAKU ZASSHI, vol. 130, no. 3, 2010, pages 355 - 375
WETZLER MODI, WEMMER DAVID E.: "Facile Dimer Synthesis for DNA-Binding Polyamide Ligands", ORGANIC LETTERS, vol. 12, no. 15, 6 August 2010 (2010-08-06), US , pages 3488 - 3490, XP055863309, ISSN: 1523-7060, DOI: 10.1021/ol1013262
MURATA, T ET AL., PEPTIDE SCIENCE, vol. 2019, 7 May 2020 (2020-05-07), pages 53 - 54
WETZLER MODI, WEMMER DAVID E.: "Facile Dimer Synthesis for DNA-Binding Polyamide Ligands", ORGANIC LETTERS, vol. 12, no. 15, 6 August 2010 (2010-08-06), US , pages 3488 - 3490, XP055863309, ISSN: 1523-7060, DOI: 10.1021/ol1013262
MURATA, T ET AL., PEPTIDE SCIENCE, vol. 2019, 7 May 2020 (2020-05-07), pages 53 - 54
Attorney, Agent or Firm:
USFI PATENT ATTORNEYS INTERNATIONAL OFFICE (JP)
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