METHOD FOR PRODUCING AMINO ACID DERIVATIVE

WIPO Patent Application WO/2016/021711

A1

　The present invention addresses the problem of providing a method for inexpensively, stably and industrially producing, at high yields, lacosamide having high optical purity. The abovementioned problem is solved by providing a method for inexpensively, stably and industrially producing, at high yields, lacosamide having high optical purity is made possible by implementing, as a key step, amination using benzylamine or a derivative thereof. The abovementioned problem is further solved by providing an intermediate that is useful in the production of lacosamide.

SEKI MASAHIKO (JP)

PCT/JP2015/072474

February 11, 2016

August 07, 2015

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API CORP (JP)

C07C231/12; A61K31/16; A61P25/08; A61P29/00; C07C231/02; C07C231/20; C07C231/24; C07C237/06; C07B53/00; C07B57/00; C07B61/00

WO2014068333A2	2014-05-08
WO2012069855A1	2012-05-31

JP2000509068A	2000-07-18
JP2012508162A
JP2013518092A	2013-05-20
JPH0570415A	1993-03-23

MIYAZAKI, H. ET AL.: "Preparations of Optically Active Homocysteine and Homocystine by Asymmetric Transformation of (RS)-1,3-Thiazane- 4-carboxylic Acid", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 66, no. 2, 1993, pages 536 - 540, XP003005639, DOI: doi:10.1246/bcsj.66.536
CLARK, J.C. ET AL.: "A new asymmetric transformation of alpha-amino-acid esters with (+)- tartaric acid", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS, vol. 1, no. Issue 5, 1976, pages 475 - 481, XP009141642

TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)

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