Title:
METHOD FOR PRODUCING ANIMAL MODEL HAVING COLON POLYP OR COLORECTAL CANCER BY USING INTESTINAL FLORA
Document Type and Number:
WIPO Patent Application WO/2018/169198
Kind Code:
A1
Abstract:
The present invention relates to a method for producing an animal model having a colon polyp or colorectal cancer by using intestinal flora. An animal model, which exhibits a significantly higher colon polyp occurrence efficiency than a conventional animal model having a colon polyp, has been identified by using an Enterotoxigenic Bacteroides fragilis (ETBF) strain, which is human intestinal flora, and a novel mouse model for research on the mechanism of colorectal diseases caused by an ETBF strain has been developed.
Inventors:
RHEE KI-JONG (KR)
HWANG SOONJAE (KR)
JO MINJEONG (KR)
HWANG SOONJAE (KR)
JO MINJEONG (KR)
Application Number:
PCT/KR2018/000952
Publication Date:
September 20, 2018
Filing Date:
January 22, 2018
Export Citation:
Assignee:
UNIV INDUSTRY FOUNDATION YONSEI UNIV WONJU CAMPUS (KR)
International Classes:
A01K67/027; G01N33/50
Other References:
ZACKULAR, J. P .: "The gut microbiome modulates colon tumorigenesis", MBIO, vol. 4, no. 6, 5 November 2013 (2013-11-05), pages e00692 - 13, XP055152082, DOI: doi:10.1128/mBio.00692-13
KANG, KUM SOON: "Evaluation of Colitis in Enterotoxigenic Bacteroides Fragilis-infected Rats", MASTER`S THESES , DEPARTMENT OF BBIOMEDICAL LIFE SCIENCE,, 2015, pages i-iv, 1 - 48
TAKAHASHI, T.: "A novel mouse model of rectal cancer established by orthotopic implantation of colon cancer cells", CANCER SCIENCE,, vol. 5, no. 6, 9 June 2004 (2004-06-09), pages 514 - 519, XP055322920, DOI: doi:10.1111/j.1349-7006.2004.tb03242.x
WU, S.: "A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses", NATURE MEDICINE, vol. 15, no. 9, 23 August 2009 (2009-08-23), pages 1016 - 1023, XP055051989
GWON, S.-Y.: "Enterotoxigenic Bacteroides fragilis-associated diseases and detection", KOREAN J. CLIN. LAB SCI., vol. 7, no. 4, 4 December 2015 (2015-12-04), pages 161 - 167, XP055608800
KANG, KUM SOON: "Evaluation of Colitis in Enterotoxigenic Bacteroides Fragilis-infected Rats", MASTER`S THESES , DEPARTMENT OF BBIOMEDICAL LIFE SCIENCE,, 2015, pages i-iv, 1 - 48
TAKAHASHI, T.: "A novel mouse model of rectal cancer established by orthotopic implantation of colon cancer cells", CANCER SCIENCE,, vol. 5, no. 6, 9 June 2004 (2004-06-09), pages 514 - 519, XP055322920, DOI: doi:10.1111/j.1349-7006.2004.tb03242.x
WU, S.: "A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses", NATURE MEDICINE, vol. 15, no. 9, 23 August 2009 (2009-08-23), pages 1016 - 1023, XP055051989
GWON, S.-Y.: "Enterotoxigenic Bacteroides fragilis-associated diseases and detection", KOREAN J. CLIN. LAB SCI., vol. 7, no. 4, 4 December 2015 (2015-12-04), pages 161 - 167, XP055608800
Attorney, Agent or Firm:
NAM, Yeon Jeong (KR)
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