Title:
METHOD FOR PRODUCING ANTITUMOR AGENT USING HOMOGENIZER
Document Type and Number:
WIPO Patent Application WO/2016/031796
Kind Code:
A1
Abstract:
Provided is a method for producing eribulin and a salt thereof efficiently and at high yield by a method for producing a compound represented by formula (II), the method including a step for stirring a reactant in the presence of manganese powder and a chromium compound using a homogenizer. (In the formula, PG1, PG2, and PG3 each independently represent hydroxyl protecting groups.)
Inventors:
CHIBA HIROYUKI (JP)
FUKUYAMA TAKASHI (JP)
TAKIGAWA TEIJI (JP)
FUKUYAMA TAKASHI (JP)
TAKIGAWA TEIJI (JP)
Application Number:
PCT/JP2015/073787
Publication Date:
March 03, 2016
Filing Date:
August 25, 2015
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
C07F7/18; C07D493/04; C07D493/22; C07B61/00
Foreign References:
| JP2011504166A | 2011-02-03 | |||
| JP2010285428A | 2010-12-24 | |||
| JPH10128113A | 1998-05-19 | |||
| JP2003513068A | 2003-04-08 |
Other References:
See also references of EP 3187500A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Yoshiki Hasegawa (JP)
Yoshiki Hasegawa (JP)
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