Title:
METHOD FOR PRODUCING CADAVERINE
Document Type and Number:
WIPO Patent Application WO/2012/077744
Kind Code:
A1
Abstract:
Disclosed is a novel method for producing cadaverine, said method being able to produce cadaverine at a higher yield and a greater efficiency than production methods by means of conventional fermentation methods. The method for producing cadaverine includes the culturing of coryneform bacteria that have the ability to produce cadaverine and that have resistance to pHs at or below 5.5. Preferably, the coryneform bacteria have lysine decarboxylase activity, and preferably, the coryneform bacteria have homoserine auxotrophy and/or S-(2-aminoethyl)-L-cysteine resistance.
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Inventors:
SASAKI NANAMI (JP)
MIMITSUKA TAKASHI (JP)
SAWAI HIDEKI (JP)
SAWAI KENJI (JP)
MIMITSUKA TAKASHI (JP)
SAWAI HIDEKI (JP)
SAWAI KENJI (JP)
Application Number:
PCT/JP2011/078394
Publication Date:
June 14, 2012
Filing Date:
December 08, 2011
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
SASAKI NANAMI (JP)
MIMITSUKA TAKASHI (JP)
SAWAI HIDEKI (JP)
SAWAI KENJI (JP)
SASAKI NANAMI (JP)
MIMITSUKA TAKASHI (JP)
SAWAI HIDEKI (JP)
SAWAI KENJI (JP)
International Classes:
C12P13/00; C12N15/09
Domestic Patent References:
| WO2007113127A1 | 2007-10-11 | |||
| WO2008101850A1 | 2008-08-28 | |||
| WO2008092720A1 | 2008-08-07 |
Foreign References:
| JP2004222569A | 2004-08-12 | |||
| JP2004222569A | 2004-08-12 | |||
| JP2002223770A | 2002-08-13 | |||
| JP2008104453A | 2008-05-08 | |||
| JP2009207495A | 2009-09-17 | |||
| JP2009029872A | 2009-02-12 | |||
| JP2009028045A | 2009-02-12 |
Other References:
MOREAU, P.L. ET AL.: "The lysine decarboxylase CadA protects Escherichia coli starved of phosphate against fermentation acids.", J BACTERIOL., vol. 189, 2007, pages 2249 - 2261, XP055087423
BOWER, J.M. ET AL.: "Polyamine-mediated resistance of uropathogenic Escherichia coli to nitrosative stress.", J BACTERIOL., vol. 188, 2006, pages 928 - 933, XP055087426
TANAKA, Y. ET AL.: "Lysine decarboxylase of Vibrio parahaemolyticus: kinetics of transcription and role in acid resistance.", J APPL MICROBIOL., vol. 104, 2008, pages 1283 - 1293, XP055087427
PARK, Y.K. ET AL.: "Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium.", MOL MICROBIOL., vol. 20, 1996, pages 605 - 611, XP055087429
MANUEL, J. ET AL.: "Cadaverine suppresses persistence to carboxypenicillins in Pseudomonas aeruginosa PA01.", ANTIMICROB AGENTS CHEMOTHER., vol. 54, 2010, pages 5173 - 5179, XP055087430
STEFAINE KIND, METABOLIC ENGINEERING, vol. 12, 2010, pages 341 - 351
INT. J. SYST., BACTERIOL., vol. 41, 1981, pages 225
"Current Protocols I Molecular Biology", 1987, JOHN WILY & SONS
SAMBROOK ET AL.: "Molecular Clonig: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"DNA Cloning: A Practical Approach", vol. I, II, 1985
"Current Protocols in Molecular Biology", 1994, JOHN WILEY & SONS, INC.
"PCR Technology: Principles and Application for DNA Amplication", STOCKTON PRESS
GENE, vol. 39, 1985, pages 281 - 286
BIO/TECHNOLOGY, vol. 7, 1989, pages 1067 - 1070
FEMS MICROBIOLOGY LETTERS, vol. 65, 1989, pages 299
BOWER, J.M. ET AL.: "Polyamine-mediated resistance of uropathogenic Escherichia coli to nitrosative stress.", J BACTERIOL., vol. 188, 2006, pages 928 - 933, XP055087426
TANAKA, Y. ET AL.: "Lysine decarboxylase of Vibrio parahaemolyticus: kinetics of transcription and role in acid resistance.", J APPL MICROBIOL., vol. 104, 2008, pages 1283 - 1293, XP055087427
PARK, Y.K. ET AL.: "Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium.", MOL MICROBIOL., vol. 20, 1996, pages 605 - 611, XP055087429
MANUEL, J. ET AL.: "Cadaverine suppresses persistence to carboxypenicillins in Pseudomonas aeruginosa PA01.", ANTIMICROB AGENTS CHEMOTHER., vol. 54, 2010, pages 5173 - 5179, XP055087430
STEFAINE KIND, METABOLIC ENGINEERING, vol. 12, 2010, pages 341 - 351
INT. J. SYST., BACTERIOL., vol. 41, 1981, pages 225
"Current Protocols I Molecular Biology", 1987, JOHN WILY & SONS
SAMBROOK ET AL.: "Molecular Clonig: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"DNA Cloning: A Practical Approach", vol. I, II, 1985
"Current Protocols in Molecular Biology", 1994, JOHN WILEY & SONS, INC.
"PCR Technology: Principles and Application for DNA Amplication", STOCKTON PRESS
GENE, vol. 39, 1985, pages 281 - 286
BIO/TECHNOLOGY, vol. 7, 1989, pages 1067 - 1070
FEMS MICROBIOLOGY LETTERS, vol. 65, 1989, pages 299
Attorney, Agent or Firm:
TANIGAWA, Hidejiro (JP)
Mountain stream Eijiro (JP)
Mountain stream Eijiro (JP)
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