Title:
METHOD FOR PRODUCING CAROTENOIDS EACH HAVING 50 CARBON ATOMS
Document Type and Number:
WIPO Patent Application WO/2012/169623
Kind Code:
A1
Abstract:
The present invention provides a method for producing various types of carotenoids each having 50 carbon atoms by desaturating carotenoids each having 50 carbon atoms with high efficiency, said method being comprising culturing a cell that is transformed with a mutant phytoene desaturase gene in a culture medium and obtaining carotenoids each having 50 carbon atoms from the culture. The mutant phytoene desaturase gene is produced by introducing a mutation so as to encode a mutant phytoene desaturase of which the activity of desaturating a carotenoid-skeleton compound having 50 carbon atoms is enhanced.
Inventors:
UMENO DAISUKE (JP)
FURUBAYASHI MAIKO (JP)
MISAWA NORIHIKO (JP)
TAKAICHI SHINICHI (JP)
FURUBAYASHI MAIKO (JP)
MISAWA NORIHIKO (JP)
TAKAICHI SHINICHI (JP)
Application Number:
PCT/JP2012/064817
Publication Date:
December 13, 2012
Filing Date:
June 08, 2012
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
UMENO DAISUKE (JP)
FURUBAYASHI MAIKO (JP)
MISAWA NORIHIKO (JP)
TAKAICHI SHINICHI (JP)
UMENO DAISUKE (JP)
FURUBAYASHI MAIKO (JP)
MISAWA NORIHIKO (JP)
TAKAICHI SHINICHI (JP)
International Classes:
C12N15/09; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12P5/00; C12P5/02
Foreign References:
| JPH10248575A | 1998-09-22 | |||
| JPH10327865A | 1998-12-15 |
Other References:
TOBIAS A.V. ET AL.: "Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways.", BIOCHIM.BIOPHYS. ACTA., vol. 61, no. 2, 17 February 2006 (2006-02-17), pages 235 - 246
UMENO D. ET AL.: "Diversifying carotenoid biosynthetic pathways by directed evolution.", MICROBIOL.MOL.BIOL.REV., vol. 9, no. 1, 6 March 2005 (2005-03-06), pages 51 - 78
ALBERMANN C.: "High versus low level expression of the lycopene biosynthesis genes from Pantoea ananatis in Escherichia coli.", BIOTECHNOL.LETT., vol. 3, no. 2, 3 February 2011 (2011-02-03), pages 313 - 319
NORIHIKO MISAWA: "Carotenoid biosynthesis genes and biotechnology", FFI JOURNAL, vol. 212, no. 7, 2007, pages 532 - 538
STICKFORTH P. ET AL.: "Structural and kinetics properties of a mutated phytoene desaturase from Rubrivivax gelatinosus with modified product specificity.", ARCH.BIOCHEM.BIOPHYS., vol. 505, no. 1, 1 January 2011 (2011-01-01), pages 118 - 122
UMENO D. ET AL.: "Diversifying carotenoid biosynthetic pathways by directed evolution.", MICROBIOL.MOL.BIOL.REV., vol. 9, no. 1, 6 March 2005 (2005-03-06), pages 51 - 78
ALBERMANN C.: "High versus low level expression of the lycopene biosynthesis genes from Pantoea ananatis in Escherichia coli.", BIOTECHNOL.LETT., vol. 3, no. 2, 3 February 2011 (2011-02-03), pages 313 - 319
NORIHIKO MISAWA: "Carotenoid biosynthesis genes and biotechnology", FFI JOURNAL, vol. 212, no. 7, 2007, pages 532 - 538
STICKFORTH P. ET AL.: "Structural and kinetics properties of a mutated phytoene desaturase from Rubrivivax gelatinosus with modified product specificity.", ARCH.BIOCHEM.BIOPHYS., vol. 505, no. 1, 1 January 2011 (2011-01-01), pages 118 - 122
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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