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Title:
METHOD FOR PRODUCING CONTRAST AGENTS LARGELY FREE OF SIDE-EFFECTS
Document Type and Number:
WIPO Patent Application WO1999010015
Kind Code:
A3
Abstract:
To reduce the allergic or pseudo-allergic side-effects of X-ray contrast agents, the contrast agent is pre-incubated in vitro with a reactive medium such as human or animal blood protein, after which the resulting reaction products are separated from the contrast agent by ultrafiltration.

Inventors:
SIXT BERNHARD (DE)
Application Number:
PCT/EP1998/005305
Publication Date:
May 06, 1999
Filing Date:
August 20, 1998
Export Citation:
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Assignee:
SIXT BERNHARD (DE)
International Classes:
A61K49/04; B01D61/14; (IPC1-7): A61K49/04
Domestic Patent References:
WO1997030735A21997-08-28
WO1992014539A11992-09-03
WO1994014478A11994-07-07
Foreign References:
EP0312104A21989-04-19
EP0882454A21998-12-09
US5779905A1998-07-14
US5550287A1996-08-27
US5204005A1993-04-20
Other References:
VON BARTHELD, C. S.: "Radio-iodination of neurotrophins and their delivery in vivo: advantages of membrane filtration and the use of disposable syringes", JOURNAL OF NEUROSCIENCE METHODS, 1998, pages 207 - 215, XP002090454
FABER, J. ET AL: "Serum free T4, T3, rT3, 3,3'-diiodothyronine and 3',5'-diiodothyronine measured by ultrafiltration", ACTA ENDOCRINOLOGICA, 1984, XP002090356
KAZIKIEWICZ J M ET AL: "RAPID MINIATURIZED CHROMATOGRAPHY PROCEDURES FOR IODINATED MONOCLONAL ANTIBODIES COMPARISON TO GEL EXCLUSION CHROMATOGRAPHY", J NUCL MED TECHNOL, XP002090126
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