Title:
METHOD FOR PRODUCING CROSS-LINKED NUCLEIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/109384
Kind Code:
A1
Abstract:
The present invention provides a method for producing an amide cross-linked nucleic acid derivative, which is useful as a molecule for use as an antisense, with high efficiency. An intermediate that is important for the synthesis of an amide cross-linked nucleic acid derivative can be synthesized with high efficiency by carrying out an aldol reaction under specified conditions. The intermediate can be ring-closed with high efficiency by removing a protective group therefrom.
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Inventors:
OBIKA SATOSHI (JP)
MIKAMIYAMA HIDENORI (JP)
ADACHI YOU (JP)
MIYAKE NAOKI (JP)
SAKAGAMI MASAHIRO (JP)
TANINO TETSUYA (JP)
ANAN KOSUKE (JP)
SEKIGUCHI MITSUAKI (JP)
KURODA NORIKAZU (JP)
MIKAMIYAMA HIDENORI (JP)
ADACHI YOU (JP)
MIYAKE NAOKI (JP)
SAKAGAMI MASAHIRO (JP)
TANINO TETSUYA (JP)
ANAN KOSUKE (JP)
SEKIGUCHI MITSUAKI (JP)
KURODA NORIKAZU (JP)
Application Number:
PCT/JP2014/050325
Publication Date:
July 17, 2014
Filing Date:
January 10, 2014
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UNIV OSAKA (JP)
UNIV OSAKA (JP)
International Classes:
C07H19/06
Domestic Patent References:
| WO2011052436A1 | 2011-05-05 | |||
| WO2000000456A1 | 2000-01-06 | |||
| WO2012029870A1 | 2012-03-08 |
Foreign References:
| JPH01503069A | 1989-10-19 |
Other References:
YOSHIYUKI HARI ET AL.: "Synthesis and duplex- forming ability of oligonucleotides containing 4'-carboxythymidine analogst", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10, no. 48, 28 December 2012 (2012-12-28), pages 9639 - 9649
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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