Title:
METHOD FOR PRODUCING CRYSTALS OF DIAZABICYCLOOCTANE DERIVATIVE AND STABLE LYOPHILIZED PREPARATION
Document Type and Number:
WIPO Patent Application WO/2016/088863
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method with which it is possible to easily produce crystals of compound (I) on an industrial scale, and to provide a stable lyophilized composition of said compound (I). It was discovered that a lyophilized composition having exceptional storage stability and in which compound (I) is in crystalline form can be obtained by lyophilizing an aqueous solution that contains said compound (I) and an inorganic salt such as sodium chloride, and that crystals of said compound (I) can be obtained from said aqueous solution even without lyophilization.
Inventors:
OGAWA TAKAYA (JP)
YOKOYAMA TAKUYA (JP)
FURUYAMA SHUSUKE (JP)
ICHIKI MASATO (JP)
FUSHIHARA KENICHI (JP)
YOKOYAMA TAKUYA (JP)
FURUYAMA SHUSUKE (JP)
ICHIKI MASATO (JP)
FUSHIHARA KENICHI (JP)
Application Number:
PCT/JP2015/084094
Publication Date:
June 09, 2016
Filing Date:
December 04, 2015
Export Citation:
Assignee:
MEIJI SEIKA PHARMA CO LTD (JP)
International Classes:
A61K9/19; C07D471/08; A61K31/439; A61K47/04; A61P43/00
Domestic Patent References:
| WO2013180197A1 | 2013-12-05 | |||
| WO1995029913A1 | 1995-11-09 | |||
| WO2015053297A1 | 2015-04-16 |
Other References:
NORIAKI HIRAYAMA, YUKI KAGOBUTSU KESSHO SAKUSEI: "Handbook -Genri to Know How-, Maruzen Co., Ltd", 25 July 2008, pages: 57 - 84, XP008183996
See also references of EP 3228620A4
See also references of EP 3228620A4
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
Patent business corporation Tsukuni (JP)
Patent business corporation Tsukuni (JP)
Download PDF: