Title:
METHOD OF PRODUCING DRUG-CONTAINING WAX MATRIX PARTICLES, EXTRUDER TO BE USED IN THE METHOD AND SUSTAINED-RELEASE PREPARATION CONTAINING CILOSTAZOL
Document Type and Number:
WIPO Patent Application WO/2007/072908
Kind Code:
A1
Abstract:
It is intended to provide a method of conveniently producing drug-containing
wax matrix particles (in particular, drug-containing wax matrix particles
having an average particle diameter of 1 mm or less) through melting and spraying
steps without suffering from a jamming failure caused by the recrystallization
of the once molten drug. Namely, drug-containing wax matrix particles containing
a drug and a wax are produced via the following steps (i) and (ii): (i) the step of
feeding the drug and wax as described above into an extruder wherein the temperatures
of a barrel (1) and a die have been controlled to a level higher than the melting
point of the wax; and (ii) the step of melt-kneading the drug with the wax in the
extruder as described above and simultaneously spraying out the melt-kneaded
mixture comprising the drug and the wax from a spray nozzle (5), which is attached
directly to a die (3) provided at the tip of the barrel (1) in the extruder, into
an atmosphere at a temperature lower than the melting point of the wax to thereby
form particles.
Inventors:
TOMOHIRA YUSO (JP)
YAMAGUCHI YASUO (JP)
YAMAGUCHI YASUO (JP)
Application Number:
PCT/JP2006/325501
Publication Date:
June 28, 2007
Filing Date:
December 21, 2006
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
TOMOHIRA YUSO (JP)
YAMAGUCHI YASUO (JP)
TOMOHIRA YUSO (JP)
YAMAGUCHI YASUO (JP)
International Classes:
A61J3/06; A61K9/14; A61K31/4709; A61K31/522; A61K47/12; A61K47/14; A61K47/44; B01J2/04
Domestic Patent References:
| WO2005000312A1 | 2005-01-06 |
Foreign References:
| JP2005162733A | 2005-06-23 |
Other References:
See also references of EP 1970040A4
Attorney, Agent or Firm:
SAEGUSA, Eiji et al. (1-7-1 Doshomachi, Chuo-k, Osaka-shi Osaka 45, JP)
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