METHOD FOR PRODUCING EPOXY ALCOHOL COMPOUND

Title:

METHOD FOR PRODUCING EPOXY ALCOHOL COMPOUND

Document Type and Number:

WIPO Patent Application WO/2019/031240

Kind Code:

A1

Abstract:

The present invention makes it possible to obtain a compound represented by formula (II) at a high yield by executing: a step A for obtaining a trimethyl oxosulfonium ylide solution or a trimethyl sulfonium ylide solution by reacting a base and a trimethyl oxosulfonium salt or a trimethyl sulfonium salt with one another in a solvent, and removing the solid which is produced; and a step B for obtaining a compound represented by formula (II) by reacting the solution obtained in step A with a compound represented by formula (I) (In the formula, Ar represents a phenyl group which may be substituted with one to three substituent groups selected from the group consisting of a halogen atom and a trifluoromethyl group, and R represents a hydrogen atom or a C1-12 alkyl group). It is possible to derive from the compound represented by formula (II) a compound represented by formula (V), which is useful as a production intermediate for an antifungal agent.

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WO/2007/074091	EPOXIDE INTERMEDIATE IN THE TAMIFLU SYNTHESIS

Inventors:

ANDO KENICHI (JP)
TANAKA YOHEI (JP)
KAWAMI KOH (JP)

Application Number:

PCT/JP2018/027835

Publication Date:

February 14, 2019

Filing Date:

July 25, 2018

Export Citation:

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Assignee:

SUMITOMO CHEMICAL CO (JP)

International Classes:

C07D301/02; C07D249/08; C07D303/12; C07D303/14; C07D405/06

Domestic Patent References:

WO2012053659A1	2012-04-26
WO2004000826A1	2003-12-31
WO2007062542A2	2007-06-07
WO2012053659A1	2012-04-26

Foreign References:

JPH07500569A	1995-01-19
JP2004513934A	2004-05-13
US5620994A	1997-04-15
US5807854A	1998-09-15
US6884892B2	2005-04-26
JPH04356471A	1992-12-10
US5177094A	1993-01-05

Other References:

"Encyclopedia of Reagents for Organic Synthesis", pages: 4336
See also references of EP 3666762A4

Attorney, Agent or Firm:

NAKAYAMA, Tohru et al. (JP)

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