Title:
METHOD FOR PRODUCING EVEROLIMUS
Document Type and Number:
WIPO Patent Application WO/2023/022213
Kind Code:
A1
Abstract:
[Problem] To enable providing of, in a method for producing highly pure everolimus, a low cost purification step which enables efficient acquisition of highly pure everolimus from crude everolimus, and of which the safety has been confirmed. [Solution] According to the present invention, a step for purifying crude everolimus is executed by using a diol silica gel as a stationary phase, using a mixed solution of ethyl acetate and heptane as an eluent, and using a hydrophilic solvent as an added solvent to the eluent.
Inventors:
KURISU HIRONOSUKE (JP)
HIBINO KAZUHIRO (JP)
KANDA YASUHISA (JP)
NISHIMURA YUTAKA (JP)
HIBINO KAZUHIRO (JP)
KANDA YASUHISA (JP)
NISHIMURA YUTAKA (JP)
Application Number:
PCT/JP2022/031301
Publication Date:
February 23, 2023
Filing Date:
August 19, 2022
Export Citation:
Assignee:
MICROBIOPHARM JAPAN CO LTD (JP)
International Classes:
C07D498/18; A61K31/436; A61P35/00; A61P37/06; B01D15/32; B01J20/10; B01J20/28
Domestic Patent References:
| WO2020194209A1 | 2020-10-01 |
Foreign References:
| JP2016523246A | 2016-08-08 | |||
| CN104086564A | 2014-10-08 | |||
| JP2002531527A | 2002-09-24 | |||
| CN102174053A | 2011-09-07 | |||
| CN102464668A | 2012-05-23 |
Other References:
ANONYMOUS: "Inertsil NH2; Inertsil Diol", GENERAL CATALOG 31, GL SCIENCES INC, JP, no. 31, 28 February 2019 (2019-02-28), JP, pages 169 - 170, XP009544093
Attorney, Agent or Firm:
PATENT PROFESSION CORPORATION ODAJIMA PATENT OFFICE (JP)
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