Title:
METHOD FOR PRODUCING EXOSOMES WITH ENHANCED ANTIVIRAL ACTIVITY AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/027403
Kind Code:
A1
Abstract:
The present invention provides a method for producing exosomes with enhanced antiviral activity, comprising a step of culturing cells in a medium including interferon-α, or a combination of interferon-α and interferon-β. According to the present invention, exosomes with enhanced antiviral activity can be provided, and there can be provided: a pharmaceutical composition effective in the prevention, alleviation or treatment of viral infection; and a pharmaceutical composition for the prevention, suppression, alleviation, amelioration or treatment of diseases caused by viral infection, for example, sore throat, bronchitis, pneumonia, chronic obstructive pulmonary disease, acute respiratory distress syndrome, and/or other respiratory system-related diseases, the compositions using the exosomes.
Inventors:
CHO BYONG SEUNG (KR)
Application Number:
PCT/KR2022/012151
Publication Date:
March 02, 2023
Filing Date:
August 15, 2022
Export Citation:
Assignee:
EXOCOBIO INC (KR)
International Classes:
C12N5/077; A61K35/35; A61P31/12; C12N5/0775
Domestic Patent References:
| WO2021021572A1 | 2021-02-04 |
Foreign References:
| KR102159914B1 | 2020-09-24 | |||
| KR20200142636A | 2020-12-23 |
Other References:
LI JIANHUA, LIU KUANCHENG, LIU YANG, XU YAN, ZHANG FEI, YANG HUIJUAN, LIU JIANGXIA, PAN TINGTING, CHEN JIELIANG, WU MIN, ZHOU XIAO: "Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity", NATURE IMMULOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 14, no. 8, 1 August 2013 (2013-08-01), New York , pages 793 - 803, XP093039957, ISSN: 1529-2908, DOI: 10.1038/ni.2647
POPOWSKI KRISTEN D., DINH PHUONG‐UYEN C., GEORGE ARIANNA, LUTZ HALLE, CHENG KE: "Exosome therapeutics for COVID‐19 and respiratory viruses", VIEW, vol. 2, no. 3, 1 June 2021 (2021-06-01), pages 20200186, XP093039959, ISSN: 2688-268X, DOI: 10.1002/VIW.20200186
POPOWSKI KRISTEN D., DINH PHUONG‐UYEN C., GEORGE ARIANNA, LUTZ HALLE, CHENG KE: "Exosome therapeutics for COVID‐19 and respiratory viruses", VIEW, vol. 2, no. 3, 1 June 2021 (2021-06-01), pages 20200186, XP093039959, ISSN: 2688-268X, DOI: 10.1002/VIW.20200186
Attorney, Agent or Firm:
LEE, Dong-Ki (KR)
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